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L-去甲肾上腺素酒石酸氢盐

L-去甲肾上腺素酒石酸氢盐用途

Norepinephrine tartrate (Levarterenol tartrate) 是一种天然的应激激素和神经递质,是 β1 选择性的adrenergic receptor激动剂,EC50值为 5.37 μM。

L-去甲肾上腺素酒石酸氢盐名称

[ CAS 号 ]:
51-40-1

[ 中文名 ]:
重酒石酸去甲肾上腺素

[ 英文名 ]:
Noradrenaline tartrate

[中文别名 ]:

[英文别名 ]:

Norepinephrine Bitartrate
l-noradrenalinetartrate
noradrenaline bitartrate
Levarterenolbitartrate
MFCD00036384
Leverterenol bitartrate
noradrenalinetartrate
L-ARTERENOL BITARTRATE
Noradrenalineacidtartrate
NORADRENALINE

L-去甲肾上腺素酒石酸氢盐生物活性

[ 描述 ]:

Norepinephrine tartrate (Levarterenol tartrate) 是一种天然的应激激素和神经递质,是 β1 选择性的adrenergic receptor激动剂,EC50值为 5.37 μM。

[ 相关类别 ]:

研究领域 >> 心血管疾病

研究领域 >> 内分泌

信号通路 >> 自噬 >> 自噬

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

[ 靶点 ]

EC50: 5.37 μM (β1-selective adrenergic receptor)[1].

[体外研究]

酒石酸去甲肾上腺素(NE)被认为是一种β1亚型选择性肾上腺素能激动剂。去甲肾上腺素(NE)在较高浓度下对β2肾上腺素受体也有直接活性[1]。从新生野生型C57BL/6J小鼠腹股沟脂肪垫(iWA)或肩胛间脂肪垫(BA)中分离并培养脂肪细胞。为了检验激活AT2对β-肾上腺素能信号传导的影响,首先评估有无CGP(10 nM)co处理的去甲肾上腺素(NE,10µM)的反应[2]。去甲肾上腺素(NE)在iWA中如预期增加cAMP,而CGP并没有改变这种作用去甲肾上腺素(NE)也被认为可以诱导脂解,释放的脂肪酸需要功能性地激活UCP1蛋白和刺激产热。在小鼠iWA中,Ser133处的CREB磷酸化在去甲肾上腺素(NE)处理后增加,而CGP-co处理显著减弱[2]。RT-PCR[2]细胞系：皮下前脂肪细胞脂肪细胞。浓度：10μM,培养时间：6小时。肾上腺素诱导的脂肪细胞活化抑制(肾上腺素2)

[参考文献]

[1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200.

[2]. Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60.

L-去甲肾上腺素酒石酸氢盐物理化学性质

[ 沸点 ]:
442.6ºC at 760 mmHg

[ 分子式 ]:
C₁₂H₁₇NO₉

[ 分子量 ]:
319.265

[ 闪点 ]:
221.5ºC

[ 精确质量 ]:
319.090332

[ PSA ]:
201.77000

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
室温

L-去甲肾上腺素酒石酸氢盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN6750000

CAS REGISTRY NUMBER :: 51-40-1

LAST UPDATED :: 199504

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C8-H11-N-O3.C4-H6-O6

MOLECULAR WEIGHT :: 319.30

WISWESSER LINE NOTATION :: Z1YQR CQ DQ &OVYQYQVO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3987 ug/kg

TOXIC EFFECTS :: Behavioral - excitement

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1025 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - mouse Lymphocyte

DOSE/DURATION :: 100 mg/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11,523,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5302 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

L-去甲肾上腺素酒石酸氢盐安全信息

[ 危害码 (欧洲) ]:
T+

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 3249

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2922210000

L-去甲肾上腺素酒石酸氢盐海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%