红没药醇

红没药醇用途

alpha-Bisabolol 是一种存在天然精油中无毒的倍半萜烯醇,具有抗癌活性。alpha-Bisabolol 通过诱导细胞周期停滞、线粒体死亡,和抑制 PI3K/Akt 信号通路,对 A549 NSCLC 细胞产生抗癌作用 (IC50 = 15 μM)。alpha-Bisabolol 能强有力地诱导胶质瘤细胞凋亡。

红没药醇作用

作为调理剂、掩蔽剂、舒缓剂等，应用于个人护理用品领域。和皮肤相容性佳。适合于敏感皮肤。适用于防晒产品、晒后产品中。具有一定的辅助亮白、抗老作用。具有较好的炎症、粉刺等的控制能力。作为抑菌剂应用。

红没药醇名称

[ CAS 号 ]:
515-69-5

[ 中文名 ]:
红没药醇

[ 英文名 ]:
alpha-Bisabolol

[中文别名 ]:

[英文别名 ]:

MFCD03846910
)-α-Bisabolol
a-Bisabolol
α-Bisabolol
dl-a-Bisabolol
(+/-)-α-Bisabolol
EINECS 208-205-9
Dragosantol
(±)-a-Bisabolol

红没药醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[参考文献]

[1]. Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23(5):1407-1412.

[2]. Cavalieri E, et al. alpha-Bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochem Biophys Res Commun. 2004 Mar 12;315(3):589-94.

红没药醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
314.5±11.0 °C at 760 mmHg

[ 分子式 ]:
C₁₅H₂₆O

[ 分子量 ]:
222.366

[ 闪点 ]:
113.2±15.6 °C

[ 精确质量 ]:
222.198364

[ PSA ]:
20.23000

[ LogP ]:
5.07

[ 外观性状 ]:
无色或稻黄色的粘液液体

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.494

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

红没药醇MSDS

详细MSDS(安全技术说明书)

红没药醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MJ9685000

CHEMICAL NAME :: 5-Hepten-2-ol, 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-

CAS REGISTRY NUMBER :: 515-69-5

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C15-H26-O

MOLECULAR WEIGHT :: 222.41

WISWESSER LINE NOTATION :: L6UTJ A1 DXQ1&3UY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,615,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1661 No. of Facilities: 357 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 3923 (estimated) No. of Female Employees: 2853 (estimated)

红没药醇安全信息

[ 风险声明 (欧洲) ]:
R33

[ 危险品运输编码 ]:
3439.0

[ WGK德国 ]:
2

[ RTECS号 ]:
MJ9685000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29061900

红没药醇合成路线

详细合成路线

红没药醇上下游产品

红没药醇上游产品

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红没药醇海关

[ 海关编码 ]: 29061900