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甲羟孕酮

甲羟孕酮用途

Medroxyprogesterone是合成的人孕酮变体,是孕酮受体激动剂。

甲羟孕酮名称

[ CAS 号 ]:
520-85-4

[ 中文名 ]:
甲羟孕酮

[ 英文名 ]:
medroxyprogesterone

[中文别名 ]:

[英文别名 ]:

Medroxyprogesteron
Medroxyprogesteronum
Hydroxymethylprogesterone
MFCD00069474
17α-Hydroxy-6α-methylprogesterone
Medroxy Progesterone
17-Hydroxy-6α-methylprogesterone
Medrossiprogesterone
17alpha-Hydroxy-6alpha-methylprogesterone
(6a)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione

甲羟孕酮生物活性

[ 描述 ]:

Medroxyprogesterone是合成的人孕酮变体,是孕酮受体激动剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 孕激素受体

研究领域 >> 内分泌

[参考文献]

[1]. http://en.wikipedia.org/wiki/Medroxyprogesterone

甲羟孕酮物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
488.0±45.0 °C at 760 mmHg

[ 熔点 ]:
220-223.5ºC

[ 分子式 ]:
C₂₂H₃₂O₃

[ 分子量 ]:
344.488

[ 闪点 ]:
263.0±25.2 °C

[ 精确质量 ]:
344.235138

[ PSA ]:
54.37000

[ LogP ]:
3.38

[ 外观性状 ]:
固体;White to Almost white powder to crystal

[ 蒸汽压 ]:
0.0±2.8 mmHg at 25°C

[ 折射率 ]:
1.554

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
水溶性：不溶；水溶解度：2.95 mg/l 25 °C；易溶于：氯仿

甲羟孕酮MSDS

甲羟孕酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5300000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 17-hydroxy-6-alpha-methyl-

CAS REGISTRY NUMBER :: 520-85-4

BEILSTEIN REFERENCE NO. :: 2510965

LAST UPDATED :: 199706

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H32-O3

MOLECULAR WEIGHT :: 344.54

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 E1 FV1 FQ K1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 6 mg/kg/13W-I

TOXIC EFFECTS :: Peripheral Nerve and Sensation - sensory change involving peripheral nerve Behavioral - hallucinations, distorted perceptions Lungs, Thorax, or Respiration - other changes

REFERENCE :: MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914- Volume(issue)/page/year: 163,51,1995 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 17-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :: ECJPAE Endocrinologia Japonica. (Japan Pub. Trading Co., Ltd., POB 5030, Tokyo International, Tokyo, Japan) V.1- 1954- Volume(issue)/page/year: 24,77,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 625 mg/kg

SEX/DURATION :: female 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 12,445,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1120 mg/kg

SEX/DURATION :: male 16 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 187,431,1977

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 5 mg/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: 85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,57,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7306 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 339 (estimated) No. of Female Employees: 170 (estimated)

甲羟孕酮安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
48-63-68

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TU5300000

甲羟孕酮合成路线

甲羟孕酮上下游产品

甲羟孕酮上游产品

甲羟孕酮下游产品

甲羟孕酮文献

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