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槲皮苷

槲皮苷用途

槲皮苷 (Quercitrin) 是苦荞麦中的一种天然化合物,具有抗炎作用,常用于治疗心血管疾病。

槲皮苷名称

[ CAS 号 ]:
522-12-3

[ 中文名 ]:
槲皮苷

[ 英文名 ]:
Quercitrin

[中文别名 ]:

[英文别名 ]:

quercetin 3-O-α-L-rhamnopyranoside
quercetin-3-L-rhamnoside
3-O-α-rhamnosylquercetine
Quercetin 3-O-L-rhamnoside
Quercitroside
QUERCETIN 3-L-RHAMNOSIDE
EINECS 208-322-5
Thujin
Quercetin 3-O-α-L-rhamnoside
Quercetin-3-O-α-L-rhamnopyranoside

槲皮苷生物活性

[ 描述 ]:

槲皮苷 (Quercitrin) 是苦荞麦中的一种天然化合物,具有抗炎作用,常用于治疗心血管疾病。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> MAPK/ERK信号通路 >> 核糖体S6激酶(RSK)

天然产物 >> 黄酮类化合物

研究领域 >> 炎症/免疫

[参考文献]

[1]. Cincin ZB, et al. Apoptotic Effects of Quercitrin on DLD-1 Colon Cancer Cell Line. Pathol Oncol Res. 2015 Apr;21(2):333-8.

[2]. Ma JQ, et al. Quercitrin offers protection against brain injury in mice by inhibiting oxidative stress and inflammation. Food Funct. 2016 Jan 20;7(1):549-56.

[3]. Li W, et al. Quercitrin ameliorates the development of systemic lupus erythematosus-like disease in a chronic graft-versus-host murine model. Am J Physiol Renal Physiol. 2016 Feb 24:ajprenal.00249.2015.

[相关活性小分子]

槲皮苷物理化学性质

[ 密度 ]:
1.8±0.1 g/cm3

[ 沸点 ]:
814.0±65.0 °C at 760 mmHg

[ 熔点 ]:
174-183ºC

[ 分子式 ]:
C₂₁H₂₀O₁₁

[ 分子量 ]:
448.377

[ 闪点 ]:
288.3±27.8 °C

[ 精确质量 ]:
448.100555

[ PSA ]:
190.28000

[ LogP ]:
2.17

[ 蒸汽压 ]:
0.0±3.1 mmHg at 25°C

[ 折射率 ]:
1.776

[ 储存条件 ]:
2-8°C

槲皮苷MSDS

槲皮苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UZ5950000

CHEMICAL NAME :: Quercitrin

CAS REGISTRY NUMBER :: 522-12-3

BEILSTEIN REFERENCE NO. :: 0068135

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-O11

MOLECULAR WEIGHT :: 448.41

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& GQ IQ DO- BT6OTJ CQ DQ EQ F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 166 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,297,1978

槲皮苷安全信息

[ 危害码 (欧洲) ]:
Xi

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UZ5950000

槲皮苷合成路线

槲皮苷上下游产品

槲皮苷上游产品

槲皮苷下游产品

槲皮苷文献

Separation of the antioxidant compound quercitrin from Lindera obtusiloba Blume and its antimelanogenic effect on B16F10 melanoma cells.

Biosci. Biotechnol. Biochem. 77(1) , 58-64, (2013)

Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae)...

[Chemical constituents from Commelina communis].

Zhongguo Zhong Yao Za Zhi 38(19) , 3304-8, (2013)

To investigate the chemical constituents from Commelina communis, fifteen compounds were separated and purified by silica gel, Sephadex LH-20, and ODS column chromatography, and semi-preparative HPLC....

Analysis of different European hazelnut (Corylus avellana L.) cultivars: authentication, phenotypic features, and phenolic profiles.

J. Agric. Food Chem. 62(26) , 6236-46, (2014)

Hazelnuts exhibit functional properties due to their content in fatty acids and phenolic compounds that could positively affect human health. The food industry requires precise traits for morphologica...

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槲皮苷