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Chenodeoxycholic acid-d5

Chenodeoxycholic acid-d5用途

鹅去氧胆酸-d5(CDCA-d5)是氘标记的鹅去氧胆酸。鹅去氧胆酸是一种疏水性初级胆汁酸,可激活参与胆固醇代谢的核受体(FXR)。

Chenodeoxycholic acid-d5名称

[ CAS 号 ]:
52840-12-7

[ 英文名 ]:
Chenodeoxycholic acid-d5

[英文别名 ]:

Chenodeoxycholic acid-d5生物活性

[ 描述 ]:

鹅去氧胆酸-d5(CDCA-d5)是氘标记的鹅去氧胆酸。鹅去氧胆酸是一种疏水性初级胆汁酸,可激活参与胆固醇代谢的核受体(FXR)。

[ 相关类别 ]:

研究领域 >> 癌症
信号通路 >> 代谢酶/蛋白酶 >> FXR
信号通路 >> 自噬 >> 自噬
研究领域 >> 代谢疾病

[体外研究]

氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92

[3]. Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710

[4]. Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11.

[5]. Ao M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56

[6]. Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab

Chenodeoxycholic acid-d5物理化学性质

[ 分子式 ]:
C24H35D5O4

[ 分子量 ]:
397.60300

[ 精确质量 ]:
397.32400

[ PSA ]:
77.76000

[ LogP ]:
4.47790

推荐生产厂家/供应商：

公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐乾明

产品详情：Chenodeoxycholic Acid-d5 (Major)

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相关化合物

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标题：【Chenodeoxycholic acid-d5】Chenodeoxycholic acid-d5 CAS号:52840-12-7【结构式 性质 活性】-化源网 地址：https://www.chemsrc.com/amp/cas/52840-12-7_1164939.html