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1,3,7-三羟基-9H-氧杂蒽-9-酮

1,3,7-三羟基-9H-氧杂蒽-9-酮用途

芒果苷的主要代谢物龙胆素(NSC 329491)显示出最有效的5-羟色胺摄取抑制,IC50值为4.7µM[1][2]。

1,3,7-三羟基-9H-氧杂蒽-9-酮名称

[ CAS 号 ]:
529-49-7

[ 中文名 ]:
1,3,7-三羟基-9H-氧杂蒽-9-酮

[ 英文名 ]:
Gentisein

[英文别名 ]:

Gentisein
9H-Xanthen-9-one,1,3,7-trihydroxy
1,3,7-trihydroxy-9H-xanthen-9-one
1,3,7-trihydroxy-xanthen-9-one
Xanthen-9-one,1,3,7-trihydroxy
1,3,7-Trihydroxy-xanthen-9-on
XANTHONE DERIV
1,3,7-trihydroxyxanthone
1,3,7-trihydroxyxanthen-9-one

1,3,7-三羟基-9H-氧杂蒽-9-酮生物活性

[ 描述 ]:

芒果苷的主要代谢物龙胆素(NSC 329491)显示出最有效的5-羟色胺摄取抑制,IC50值为4.7µM[1][2]。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

[参考文献]

[1]. Wang H, et al. Identification and determination of four metabolites of mangiferin in rat urine. J Pharm Biomed Anal. 2007;45(5):793-798.

[2]. Tzankova, Virginia et al. (2010). Inhibition of 5-HT uptake by some constituents of Hypericum annulatum in rat brain in vitro. Pharmacologyonline. 2.

1,3,7-三羟基-9H-氧杂蒽-9-酮物理化学性质

[ 分子式 ]:
C₁₃H₈O₅

[ 分子量 ]:
244.20000

[ 精确质量 ]:
244.03700

[ PSA ]:
90.90000

[ LogP ]:
2.06300

1,3,7-三羟基-9H-氧杂蒽-9-酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ZD6122400

CHEMICAL NAME :: Xanthen-9-one, 1,3,7-trihydroxy-

CAS REGISTRY NUMBER :: 529-49-7

BEILSTEIN REFERENCE NO. :: 0384687

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H8-O5

MOLECULAR WEIGHT :: 244.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 150,141,1985

1,3,7-三羟基-9H-氧杂蒽-9-酮安全信息

[ 海关编码 ]:
2932999099

1,3,7-三羟基-9H-氧杂蒽-9-酮合成路线

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1,3,7-三羟基-9H-氧杂蒽-9-酮海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%