茴三硫

茴三硫用途

Anethole trithione是治疗口干使用的药物, 正在研究治疗癌症。

茴三硫作用

本药为胆汁成分分泌促进剂，具有以下作用特点：1.能促进胆汁的排出，使胆酸、胆色素及胆固醇等固体成分的分泌量显著增加，特别是增加胆色素分泌；2.本药还能明显增强肝脏谷胱甘肽水平，显著增强谷氨酰半胱氨酸合成酶、谷胱甘肽还原酶等活性，从而显著增强肝细胞活力，使胆汁分泌增多。能消除肝炎病灶的肝充血等症状，促进肝细胞活化，有利于肝功能恢复正常；3.本药有催涎促消化作用，能促进唾液分泌，对抗精神病药物引起的唾液减少特别有效；能促进胃肠道蠕动和肠管内气体排出，可迅速消除腹胀、便秘、口臭、恶心、腹痛等消化不良症状；4.本药还有分解胆固醇作用和解毒作用，能促进体内醇类物质快速代谢而消除，降低血中胆固醇含量并防止其沉着或附着于血管内壁；对酒精、药物、食物等引起的中毒具有很好的解毒作用和抗过敏作用；5.本药还能促进尿素的生成和排泄，有明显的利尿作用。

茴三硫名称

[ CAS 号 ]:
532-11-6

[ 中文名 ]:
胆维他

[ 英文名 ]:
Anethole trithione

[中文别名 ]:

[英文别名 ]:

Anethole trithione
Halpen
(p-Methoxyphenyl)trithiopropene
EINECS 208-528-5
Anetholetrithion
Tiotrifar
3-(p-Anisyl)trithione
MFCD00129751
Sulfarlem
3H-1,2-Dithiole-3-thione, 5-(4-methoxyphenyl)-

茴三硫生物活性

[ 描述 ]:

Anethole trithione是治疗口干使用的药物, 正在研究治疗癌症。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 癌症

[相关活性小分子]

茴三硫物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
398.1±52.0 °C at 760 mmHg

[ 熔点 ]:
23 C

[ 分子式 ]:
C₁₀H₈OS₃

[ 分子量 ]:
240.365

[ 闪点 ]:
194.6±30.7 °C

[ 精确质量 ]:
239.973724

[ PSA ]:
105.50000

[ LogP ]:
3.39

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.732

[ 储存条件 ]:
库房通风低温干燥

茴三硫毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JP1292500

CHEMICAL NAME :: 3H-1,2-Dithiole-3-thione, 5-(p-methoxyphenyl)-

CAS REGISTRY NUMBER :: 532-11-6

BEILSTEIN REFERENCE NO. :: 0158393

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H8-O-S3

MOLECULAR WEIGHT :: 240.36

WISWESSER LINE NOTATION :: T5SSYTJ CUS ER DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 25,815,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,244,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,38,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,25,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,25,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8640 mg/kg/24W-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,79,1976

茴三硫安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2930909090

茴三硫合成路线

详细合成路线

茴三硫上下游产品

茴三硫上游产品

茴三硫下游产品

茴三硫制备

茴香脑与硫磺经环合而得。反应罐中加入茴香脑、二甲基甲酰胺，搅拌，投入硫磺粉。加热至146-150℃，保温反应1.5小时。反应结束，冷至80℃，减压回收二甲基甲酰胺，将反应物料冷至66℃，加入二甲苯活性炭，加热至108℃并保温半小时，然后趁热过滤。滤液冷至0℃，结晶，过滤，水洗得粗品。经二甲苯或乙酸丁酯精制后得茴三硫成品。收率为40%。

茴三硫海关

[ 海关编码 ]: 2930909090

[ 中文概述 ]:
2930909090. 其他有机硫化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

茴三硫