DL-去甲肾上腺素盐酸盐

DL-去甲肾上腺素盐酸盐用途

DL-Norepinephrine hydrochloride 是模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。DL-Norepinephrine hydrochloride 是一种靶向 α1 adrenoceptor 和 β1 adrenoceptor 的神经递质,可降低心内膜下氧分压。

DL-去甲肾上腺素盐酸盐名称

[ CAS 号 ]:
55-27-6

[ 中文名 ]:
DL-正肾上腺素盐酸盐

[ 英文名 ]:
DL-Norepinephrine hydrochloride

[中文别名 ]:

[英文别名 ]:

NA hydrochloride
DL-NOREPINEPHRINE HCL
DL-NORADRENALIN HYDROCHLORIDE
UNII:7W3827X38V
Arterenol hydrochloride
EINECS 200-229-8
MFCD00012880
DL-Norepinephrine hydrochloride
DL-ARTERENOL HYDROCHLORIDE
DL-ARTERENOL

DL-去甲肾上腺素盐酸盐生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 内分泌

[ 靶点 ]

IC50: α1 adrenoceptor and β1 adrenoceptor[1]

[参考文献]

[1]. Matsuda H, et al. Effects of nitroglycerin, adenosine, noradrenaline, and isoproterenol on the myocardial oxygen tension. Jpn Heart J. 1979 Nov;20(6):867-79.

DL-去甲肾上腺素盐酸盐物理化学性质

[ 密度 ]:
1.397g/cm3

[ 沸点 ]:
442.6ºC at 760mmHg

[ 熔点 ]:
140-144ºC (dec.)

[ 分子式 ]:
C₈H₁₂ClNO₃

[ 分子量 ]:
205.639

[ 闪点 ]:
221.5ºC

[ 精确质量 ]:
205.050568

[ PSA ]:
86.71000

[ LogP ]:
1.59220

[ 外观性状 ]:
crystalline | off-white to tan

[ 储存条件 ]:
2-8°C

DL-去甲肾上腺素盐酸盐MSDS

DL-去甲肾上腺素盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN6650000

CHEMICAL NAME :: Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, hydrochloride-, (+-)-

CAS REGISTRY NUMBER :: 55-27-6

LAST UPDATED :: 199206

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H11-N-O3.Cl-H

MOLECULAR WEIGHT :: 205.66

WISWESSER LINE NOTATION :: Z1YQR CQ DQ &GH -R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,369,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Vascular - regional or general arteriolar constriction Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,108,1948 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 13 mg/kg

SEX/DURATION :: female 7-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 85,79,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3200 ng/kg

SEX/DURATION :: female 16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972

DL-去甲肾上腺素盐酸盐安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R25

[ 安全声明 (欧洲) ]:
36/37/39-45

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
DN6650000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2922509090

DL-去甲肾上腺素盐酸盐合成路线

DL-去甲肾上腺素盐酸盐海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

DL-去甲肾上腺素盐酸盐文献

Sympathetic activity induced by naloxone-precipitated morphine withdrawal is blocked in genetically engineered mice lacking functional CRF1 receptor.

Toxicol. Appl. Pharmacol. 283(1) , 42-9, (2015)

There is large body evidence indicating that stress can lead to cardiovascular disease. However, the exact brain areas and the mechanisms involved remain to be revealed. Here, we performed a series of...

An assessment of norepinephrine mediated hypertrophy to apoptosis transition in cardiac cells: a signal for cell death.

Chem. Biol. Interact. 225 , 54-62, (2015)

Heart is an organ which is under a constant work load that generates numerous stress responses. Heart failure is associated with increased plasma norepinephrine (NE) and hypertrophic cell death. Withi...

Relationship between noradrenaline release in the locus coeruleus and antiallodynic efficacy of analgesics in rats with painful diabetic neuropathy.

Life Sci. 92(23) , 1138-44, (2013)

In animal models of neuropathic pain, the noradrenergic descending pain inhibitory pathways from the locus coeruleus (LC) may be suppressed. However, no study has investigated the correlation between ...

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DL-去甲肾上腺素盐酸盐

DL-去甲肾上腺素盐酸盐用途

DL-去甲肾上腺素盐酸盐名称

DL-去甲肾上腺素盐酸盐生物活性

DL-去甲肾上腺素盐酸盐物理化学性质

DL-去甲肾上腺素盐酸盐MSDS

详细MSDS(安全技术说明书)

DL-去甲肾上腺素盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

DL-去甲肾上腺素盐酸盐安全信息

DL-去甲肾上腺素盐酸盐合成路线

详细合成路线

DL-去甲肾上腺素盐酸盐海关

DL-去甲肾上腺素盐酸盐文献

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DL-去甲肾上腺素 盐酸盐

DL-去甲肾上腺素 盐酸盐用途

DL-去甲肾上腺素 盐酸盐名称

DL-去甲肾上腺素 盐酸盐生物活性

DL-去甲肾上腺素 盐酸盐物理化学性质

DL-去甲肾上腺素 盐酸盐MSDS

详细MSDS(安全技术说明书)

DL-去甲肾上腺素 盐酸盐毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

DL-去甲肾上腺素 盐酸盐安全信息

DL-去甲肾上腺素 盐酸盐合成路线

详细合成路线

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DL-去甲肾上腺素盐酸盐

DL-去甲肾上腺素盐酸盐用途

DL-去甲肾上腺素盐酸盐名称

DL-去甲肾上腺素盐酸盐生物活性

DL-去甲肾上腺素盐酸盐物理化学性质

DL-去甲肾上腺素盐酸盐MSDS

DL-去甲肾上腺素盐酸盐毒性和生态

DL-去甲肾上腺素盐酸盐安全信息

DL-去甲肾上腺素盐酸盐合成路线

DL-去甲肾上腺素盐酸盐海关

DL-去甲肾上腺素盐酸盐文献