55-27-6

• 常用中文名：DL-去甲肾上腺素 盐酸盐
• 常用英文名：DL-Norepinephrine hydrochloride
• CAS号：55-27-6
• 分子式：C₈H₁₂ClNO₃
• 分子量：205.639
• 相关类别： 研究领域 内分泌
• 发布时间：2018-03-13 08:00:00
• 更新时间：2024-01-04 12:46:27
• DL-Norepinephrine hydrochloride 是模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。DL-Norepinephrine hydrochloride 是一种靶向 α1 adrenoceptor 和 β1 adrenoceptor 的神经递质,可降低心内膜下氧分压。

名称

• 中文名: DL-正肾上腺素盐酸盐
• 英文名: dl-noradrenaline hydrochloride
• 中文别名: 去甲肾上腺素盐酸盐; DL-去甲肾上腺素盐酸盐
• 英文别名: NA hydrochloride; DL-NOREPINEPHRINE HCL; DL-NORADRENALIN HYDROCHLORIDE; UNII:7W3827X38V; Arterenol hydrochloride; EINECS 200-229-8; MFCD00012880; 4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol hydrochloride (1:1); DL-Norepinephrine hydrochloride; 1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, hydrochloride (1:1); (±)-4-(2-amino-1-hydroxyethyl)-1,2-Benzenediol hydrochloride; 4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol hydrochloride (1:1); DL-ARTERENOL HYDROCHLORIDE; DL-ARTERENOL

物化性质

• 密度: 1.397g/cm3
• 沸点: 442.6ºC at 760mmHg
• 熔点: 140-144ºC (dec.)
• 分子式: C₈H₁₂ClNO₃
• 分子量: 205.639
• 闪点: 221.5ºC
• 精确质量: 205.050568
• PSA: 86.71000
• LogP: 1.59220
• 外观性状: crystalline | off-white to tan
• 储存条件: 2-8°C

生物活性

• 描述: DL-Norepinephrine hydrochloride 是模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。DL-Norepinephrine hydrochloride 是一种靶向 α1 adrenoceptor 和 β1 adrenoceptor 的神经递质,可降低心内膜下氧分压。
• 相关类别:
  研究领域 >> 内分泌
• 靶点:

  IC50: α1 adrenoceptor and β1 adrenoceptor[1]

• 参考文献:

  [1]. Matsuda H, et al. Effects of nitroglycerin, adenosine, noradrenaline, and isoproterenol on the myocardial oxygen tension. Jpn Heart J. 1979 Nov;20(6):867-79.

MSDS

Name: DL-Norepinephrine Hydrochloride 99% Material Safety Data Sheet Synonym: CAS: 55-27-6 Section 1 - Chemical Product MSDS Name:DL-Norepinephrine Hydrochloride 99% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 55-27-6 DL-Norepinephrine Hydrochloride 99 200-229-8 Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated. Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Inhalation: The toxicological properties of this substance have not been fully investigated. Inhalation of dust may cause respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 55-27-6: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Powder Color: beige Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 145.00 - 147.00 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C8H11NO3.HCl Molecular Weight: 205.64 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stability unknown. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 55-27-6: DN6650000 LD50/LC50: Not available. Carcinogenicity: DL-Norepinephrine Hydrochloride - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: ALKALOID SALTS, SOLID, N.O.S.* Hazard Class: 6.1 UN Number: 1544 Packing Group: III IMO Shipping Name: ALKALOIDS, SOLID, N.O.S. Hazard Class: 6.1 UN Number: 1544 Packing Group: III RID/ADR Shipping Name: ALKALOID SALTS, SOLID, N.O.S. Hazard Class: 6.1 UN Number: 1544 Packing group: III Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 55-27-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 55-27-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 55-27-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DN6650000 CHEMICAL NAME : Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, hydrochloride-, (+-)- CAS REGISTRY NUMBER : 55-27-6 LAST UPDATED : 199206 DATA ITEMS CITED : 5 MOLECULAR FORMULA : C8-H11-N-O3.Cl-H MOLECULAR WEIGHT : 205.66 WISWESSER LINE NOTATION : Z1YQR CQ DQ &GH -R HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 15600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,369,1948 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Vascular - regional or general arteriolar constriction Lungs, Thorax, or Respiration - acute pulmonary edema REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,108,1948 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 13 mg/kg SEX/DURATION : female 7-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 85,79,1985 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 3200 ng/kg SEX/DURATION : female 16 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : PRGLBA Prostaglandins. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1972- Volume(issue)/page/year: 2,295,1972

安全

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: P301 + P310
• 个人防护装备: Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
• 危害码 (欧洲): T
• 风险声明 (欧洲): R25
• 安全声明 (欧洲): 36/37/39-45
• 危险品运输编码: UN 2811
• WGK德国: 3
• RTECS号: DN6650000
• 包装等级: III
• 危险类别: 6.1(b)
• 海关编码: 2922509090

合成路线

1207201-66-8 ~99% 55-27-6

文献：Bernini, Roberta; Crisante, Fernanda; Barontini, Maurizio; Fabrizi, Giancarlo Synthesis, 2009 , # 22 art. no. P09409SS, p. 3838 - 3842

5090-29-9 ~95% 55-27-6

文献：NEON LABORATORIES LTD.; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; KAWLE, Ganesh Ramachandra Patent: WO2013/8247 A1, 2013 ; Location in patent: Page/Page column 10 ;

海关

海关编码	2922509090
中文概述	2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装
监管条件	A.入境货物通关单 B.出境货物通关单
检验检疫	R.进口食品卫生监督检验 S.出口食品卫生监督检验
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%