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氯己定

氯己定用途

Chlorhexidine是一种抗菌剂, 用作防腐剂和其他用途。

氯己定名称

[ CAS 号 ]:
55-56-1

[ 中文名 ]:
氯己定

[ 英文名 ]:
Chlorhexidine

[中文别名 ]:

[英文别名 ]:

Clorhexidina
Tubulicid
Peridex
chlorohexidine
Chlorhexidinum
Rotersept
EINECS 200-238-7
Chlorhexidine base
Chlorhexidin
Sterilon

氯己定生物活性

[ 描述 ]:

Chlorhexidine是一种抗菌剂, 用作防腐剂和其他用途。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

氯己定物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
591.7±60.0 °C at 760 mmHg

[ 熔点 ]:
134-136 °C(lit.)

[ 分子式 ]:
C₂₂H₃₀Cl₂N₁₀

[ 分子量 ]:
505.447

[ 闪点 ]:
311.6±32.9 °C

[ 精确质量 ]:
504.203186

[ PSA ]:
167.58000

[ LogP ]:
4.58

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.659

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
0.08 g/100 mL (20 ºC)

氯己定MSDS

详细MSDS(安全技术说明书)

氯己定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU1925000

CHEMICAL NAME :: Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-

CAS REGISTRY NUMBER :: 55-56-1

BEILSTEIN REFERENCE NO. :: 2826432

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C22-H30-Cl2-N10

MOLECULAR WEIGHT :: 505.52

WISWESSER LINE NOTATION :: GR DMYUM&MYUM&M6MYUM&MYUM&MR DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9200 uL/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2515 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 632 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 24 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 uL/kg/30D-I

TOXIC EFFECTS :: Blood - changes in leukocyte (WBC) count Biochemical - Metabolism (Intermediary) - lipids including transport Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1680 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 7 umol/disc

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 28,249,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84812 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 32 (estimated) No. of Female Employees: 32 (estimated)

氯己定安全信息

[ 符号 ]:

GHS07, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H319-H334-H335-H410

[ 警示性声明 ]:
P261-P273-P305 + P351 + P338-P342 + P311-P501

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38;R51/53

[ 安全声明 (欧洲) ]:
S26-S36/37-S60-S61

[ 危险品运输编码 ]:
UN 3077 9/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DU1925000

[ 包装等级 ]:
III

[ 危险类别 ]:
9

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氯己定文献

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氯己定