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异丁酰胺

异丁酰胺用途

【用途一】
用于有机合成，制备异丁腈等。

异丁酰胺名称

[ CAS 号 ]:
563-83-7

[ 中文名 ]:
异丁酰胺

[ 英文名 ]:
Isobutyramide

[中文别名 ]:

[英文别名 ]:

2-methylpropaneamide
EINECS 209-265-9
Propanamide, 2-methyl-
isopropylformamide
IBA
iso-Butyleneamine
isobutyrimidicacid
Isobutyramide
isobutyric amide
MFCD00008019

异丁酰胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
221.4±8.0 °C at 760 mmHg

[ 熔点 ]:
127-131 °C(lit.)

[ 分子式 ]:
C₄H₉NO

[ 分子量 ]:
87.120

[ 闪点 ]:
87.7±18.4 °C

[ 精确质量 ]:
87.068413

[ PSA ]:
43.09000

[ LogP ]:
-0.36

[ 外观性状 ]:
白色针状结晶粉末

[ 蒸汽压 ]:
0.1±0.4 mmHg at 25°C

[ 折射率 ]:
1.418

[ 储存条件 ]:
室温，密封

异丁酰胺MSDS

异丁酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX1475000

CHEMICAL NAME :: Propanamide, 2-methyl-

CAS REGISTRY NUMBER :: 563-83-7

BEILSTEIN REFERENCE NO. :: 1737615

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C4-H9-N-O

MOLECULAR WEIGHT :: 87.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5439939

异丁酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TX1475000

[ 海关编码 ]:
2924199090

异丁酰胺合成路线

异丁酰胺上下游产品

异丁酰胺上游产品

异丁酰胺下游产品

异丁酰胺制备

一、生产方法简述

由异丁酸经氯化得到异丁酰氯后，再经酰胺化而得。将异丁酰氯在强烈搅拌下滴加到浓氨水中，控制加料速度，使温度不超过15℃。加完后再搅拌1h，将混合物在减压下蒸发至干，残留物为异丁酰胺和氯化铵。向残留物中加入乙酸乙酯，煮沸10min，过滤，再经真空干燥而得成品。

异丁酰胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

异丁酰胺文献

A New Signaling Pathway for HCV Inhibition by Estrogen: GPR30 Activation Leads to Cleavage of Occludin by MMP-9.

PLoS ONE 11 , e0145212, (2016)

Poor outcome in response to hepatitis C virus, including higher viral load, hepatocellular carcinoma and cirrhosis, is more associated with men and postmenopausal women than with premenopausal women a...

Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.

Blood 101(5) , 2001-7, (2003)

Pharmacologic stimulation of fetal hemoglobin (HbF) expression may be a promising approach for the treatment of beta-thalassemia. In this study, we have investigated the HbF-inducing activity and mole...

Effects of ketoacidosis on rat apolipoprotein A1 gene expression: a link with acidosis but not with ketones.

J. Mol. Endocrinol. 25(1) , 129-39, (2000)

To determine if ketoacidosis contributes to reduced apolipoprotein A1 (apoA1) expression in insulin-deficient diabetic rats, we examined the regulation of apoA1 gene expression in response to changes ...

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