乙氧基试卤灵

乙氧基试卤灵用途

7-Ethoxyresorufin (Resorufin ethyl ether) 是细胞色素 P450 (尤其是 CYP1A1) 的荧光底物和竞争性抑制剂。7-Ethoxyresorufin 也抑制 NO 合酶 (NO synthase)。

乙氧基试卤灵名称

[ CAS 号 ]:
5725-91-7

[ 中文名 ]:
7-乙氧基-3H-吩恶嗪-3-酮

[ 英文名 ]:
7-Ethoxyresorufin

[中文别名 ]:

乙氧基试卤灵

[英文别名 ]:

resorufin, 7-ethoxy-
7-Ethoxy-3H-phenoxazin-3-one
MFCD00037661
7-Ethoxyresorufin
7-Ethoxy Resorufin
7-ethoxyphenoxazin-3-one
Resorufin ethyl ether
3H-Phenoxazin-3-one, 7-ethoxy-

乙氧基试卤灵生物活性

[ 描述 ]:

7-Ethoxyresorufin (Resorufin ethyl ether) 是细胞色素 P450 (尤其是 CYP1A1) 的荧光底物和竞争性抑制剂。7-Ethoxyresorufin 也抑制 NO 合酶 (NO synthase)。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 其他

信号通路 >> 免疫及炎症 >> 一氧化氮合酶

[参考文献]

[1]. C G Li, et al. Inhibition of NO-medicate responses by 7-ethoxyresorufin, a substrate and competitive inhibitor of cytochrome P450. Br J Pharmacol. 1996 May;118(1):57-62.

[2]. Thomas K H Chang, et al. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 2006;320:85-90.

乙氧基试卤灵物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
389.3±42.0 °C at 760 mmHg

[ 熔点 ]:
223-225ºC(lit.)

[ 分子式 ]:
C₁₄H₁₁NO₃

[ 分子量 ]:
241.242

[ 闪点 ]:
185.9±22.3 °C

[ 精确质量 ]:
241.073898

[ PSA ]:
52.33000

[ LogP ]:
2.02

[ 外观性状 ]:
红色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.624

[ 储存条件 ]:
-20°C

乙氧基试卤灵MSDS

乙氧基试卤灵安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

乙氧基试卤灵合成路线

乙氧基试卤灵上下游产品

乙氧基试卤灵上游产品

乙氧基试卤灵下游产品

乙氧基试卤灵文献

The licorice flavonoid isoliquiritigenin reduces DNA-binding activity of AhR in MCF-7 cells.

Chem. Biol. Interact. 221 , 70-6, (2014)

Licorice is derived from the rhizomes of Glycyrrhiza glabra. It has been used for confectioneries or culinary purposes. The rhizomes contain many flavonoidal compounds that have been shown to be biolo...

Inhibition of cytochrome P450 1A2-mediated metabolism and production of reactive oxygen species by heme oxygenase-1 in rat liver microsomes.

Drug Metab. Lett. 5(1) , 6-16, (2011)

Heme oxygenase-1 (HO-1) is induced in most cell types by many forms of environmental stress and is believed to play a protective role in cells exposed to oxidative stress. Metabolism by cytochromes P4...

The aryl hydrocarbon receptor pathway and the response to 3-methylcholanthrene are altered in the liver of adrenalectomized rats.

Drug Metab. Dispos. 39(1) , 83-91, (2011)

The aryl hydrocarbon receptor (AHR) is activated by 3-methylcholanthrene (MC), a polycyclic aromatic hydrocarbon, and environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Adrenalec...

更多文献