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N-乙酰基硫脲

N-乙酰基硫脲用途

【用途一】
有机合成。

N-乙酰基硫脲名称

[ CAS 号 ]:
591-08-2

[ 中文名 ]:
乙酰硫脲

[ 英文名 ]:
N-ACETYLTHIOUREA

[英文别名 ]:

N-acetyl thiourea
Acetothiourea
MFCD00004937
1-Acetylthiourea
Ethanesulfenamide, N-(aminocarbonyl)-1-oxo-
Urea,1-acetyl-2-thio
Acetylthiourea
1-(Acetylsulfanyl)urea
N'-acetyltbiocarbamide
N-Acetylthiocarbamide

N-乙酰基硫脲物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
208.6ºC at 760 mmHg

[ 熔点 ]:
165-169 °C(lit.)

[ 分子式 ]:
C₃H₆N₂O₂S

[ 分子量 ]:
134.157

[ 精确质量 ]:
134.014999

[ PSA ]:
87.21000

[ LogP ]:
-0.60

[ 外观性状 ]:
固体;White to Light yellow powder to crystal

[ 折射率 ]:
1.543

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
水溶性：微溶；可溶于：醇；微溶：乙醚

N-乙酰基硫脲MSDS

N-乙酰基硫脲毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YR7700000

CHEMICAL NAME :: Urea, 1-acetyl-2-thio-

CAS REGISTRY NUMBER :: 591-08-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C3-H6-N2-O-S

MOLECULAR WEIGHT :: 118.17

WISWESSER LINE NOTATION :: SUYZMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 97,478,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 94 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

N-乙酰基硫脲安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300

[ 警示性声明 ]:
P264-P301 + P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R23/24/25

[ 安全声明 (欧洲) ]:
S36/37/39-S45

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
YR7700000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

N-乙酰基硫脲合成路线

N-乙酰基硫脲上下游产品

N-乙酰基硫脲上游产品

N-乙酰基硫脲下游产品

N-乙酰基硫脲制备

1.由硫脲和乙酰氯反应而得。在带回流冷凝器的三口烧瓶中，加入38g硫脲，40g乙酰氯及500ml甲苯。在油浴上搅拌回流16h(不再放出氯化氢为止)蒸除甲苯，剩余物用其三倍的乙醇重结晶。得产品19g，熔点163-165℃,产率34%。

将1.1摩尔的硫帆化钠溶于500毫升热丙酮中，然后慢慢滴加1摩尔乙酞氯，加热，至乙酞氯的气味消失为止(约10分钟)。冷却，滤去氯化钠沉淀。在搅拌下，将150毫升28%的氨水慢慢加入到滤液中，然后蒸发至干。残余物用热乙醇萃取，所得粗产品在乙辞中重结晶，
也可将硫氰化钠和乙酸氯置于甲苯中回流I小时，乙醇中童结晶，得菱形晶休，熔点 165℃，产率34%.

N-乙酰基硫脲文献

[Modification of the thiobarbituric method for determining sialic acids in biological material].

Lab. Delo (9) , 15-8, (1989)

The authors have examined the possibility of replacing sodium arsenite with acetyl thiourea and of using butanol acidified with phosphoric acid in measuring sialic acids in biologic material. The resu...

Oxyhalogen-sulfur chemistry: kinetics and mechanism of oxidation of N-acetylthiourea by chlorite and chlorine dioxide.

J. Phys. Chem. A 110(7) , 2396-410, (2006)

The oxidation reactions of N-acetylthiourea (ACTU) by chlorite and chlorine dioxide were studied in slightly acidic media. The ACTU-ClO(2)(-) reaction has a complex dependence on acid with acid cataly...

Formation and structure elucidation of N-(2,3,4-tri-O-acetyl-beta-D-glucopyranosyl)-N'-acetylthiourea.

Carbohydr. Res. 344(1) , 134-5, (2009)

Treatment with concd HCl/MeOH transformed N-(tetra-O-acetyl-beta-D-glucopyranosyl)-N'-acetylthiourea, via selective cleavage of the primary alcoholic ester group, into the title compound.

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