硫代秋水仙苷

硫代秋水仙苷用途

Thiocolchicoside 是中枢神经系统中竞争性的 γ-氨基丁酸 A 型 (GABAA) 受体拮抗剂和甘氨酸受体激动剂。 Thiocolchicoside 是秋水仙碱的半合成硫衍生物。Thiocolchicoside 是一种肌肉松弛剂,具有抗炎和镇痛作用。

硫代秋水仙苷名称

[ CAS 号 ]:
602-41-5

[ 中文名 ]:
硫秋水仙苷

[ 英文名 ]:
Thiocolchicoside

[中文别名 ]:

噻可撒可

[英文别名 ]:

Thiocolchicoside
UNII:T1X8S697GT
Thiocolchicine Glycoside
R. 271
Coltramyl
Musco-ril
10-Thiocolchicoside
Tiocolchicoside

硫代秋水仙苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 跨膜转运 >> GABA受体

研究领域 >> 神经疾病

信号通路 >> 神经信号通路 >> GABA受体

[ 靶点 ]

GABAA) receptor; glycine receptor[1]

[体外研究]

Thiocolchicoside(0.001,0.1,1,10,100μM)以浓度依赖的方式降低EIPSC的振幅,这种效应在0.1μM时显著,在10μM时最大[1]。

[参考文献]

[1]. Carta M, et al. The muscle relaxant thiocolchicoside is an antagonist of GAB_AA receptor function in the central nervous system. Neuropharmacology. 2006 Sep;51(4):805-15.

硫代秋水仙苷物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
929.6±65.0 °C at 760 mmHg

[ 熔点 ]:
190-198ºC

[ 分子式 ]:
C₂₇H₃₃NO₁₀S

[ 分子量 ]:
563.617

[ 闪点 ]:
516.0±34.3 °C

[ 精确质量 ]:
563.182495

[ PSA ]:
189.31000

[ LogP ]:
-1.23

[ 外观性状 ]:
固体;Light orange to Yellow to Green powder to crystal

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.657

[ 储存条件 ]:
0-10°C;避免加热

硫代秋水仙苷MSDS

详细MSDS(安全技术说明书)

硫代秋水仙苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC2976015

CHEMICAL NAME :: Acetamide, N-(3-(beta-D-glucopyranosyloxy)-5,6,7,9-tetrahydro-1, 2-dimethoxy-10-(methy lthio)- 9-oxobenzo(a)heptalen-7-yl)-, (S)-

CAS REGISTRY NUMBER :: 602-41-5

BEILSTEIN REFERENCE NO. :: 0072205

LAST UPDATED :: 199801

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C27-H33-N-O10-S

MOLECULAR WEIGHT :: 563.67

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27500 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,533,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 15,533,1960

硫代秋水仙苷安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P301 + P312 + P330-P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
AC2976015

硫代秋水仙苷

硫代秋水仙苷用途

硫代秋水仙苷名称

硫代秋水仙苷生物活性

硫代秋水仙苷物理化学性质

硫代秋水仙苷MSDS

详细MSDS(安全技术说明书)

硫代秋水仙苷毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硫代秋水仙苷安全信息

硫代秋水仙苷合成路线

详细合成路线

硫代秋水仙苷上下游产品

硫代秋水仙苷上游产品

硫代秋水仙苷下游产品

推荐生产厂家/供应商：

相关化合物