4,4’-(2-吡啶甲基)双酚

4,4’-(2-吡啶甲基)双酚用途

Desacetyl bisacodyl 是泻药比沙可啶的活性代谢物。Desacetyl bisacodyl 诱导大鼠结肠和直肠上皮 Cl(-) 分泌。Desacetyl bisacodyl 会对结肠或直肠产生多种影响,包括增加粘液和氯化物分泌。

4,4’-(2-吡啶甲基)双酚名称

[ CAS 号 ]:
603-41-8

[ 中文名 ]:
4,4’-(2-吡啶甲基)双酚

[ 英文名 ]:
Desacetyl Bisacodyl

[中文别名 ]:

苉可硫酸钠杂质B

[英文别名 ]:

4,4'-pyridin-2-ylmethanediyl-bis-phenol
EINECS 210-039-7
Deacetylbisocodyl
DDPM
La-96
deacetylbisacodyl
Dihydroxydiphenyl-pyridyl methane

4,4’-(2-吡啶甲基)双酚生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[参考文献]

[1]. Fujita T, et, al. Desacetyl bisacodyl-induced epithelial Cl(-) secretion in rat colon and rectum. Biomed Res. 2016;37(1):13-20.

4,4’-(2-吡啶甲基)双酚物理化学性质

[ 密度 ]:
1.244g/cm3

[ 沸点 ]:
462.1ºC at 760 mmHg

[ 熔点 ]:
>200ºC (dec.)

[ 分子式 ]:
C₁₈H₁₅NO₂

[ 分子量 ]:
277.32

[ 闪点 ]:
233.3ºC

[ 精确质量 ]:
277.11000

[ PSA ]:
53.35000

[ LogP ]:
3.67300

[ 折射率 ]:
1.655

[ 储存条件 ]:
-20°C，密闭，干燥

4,4’-(2-吡啶甲基)双酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM8730000

CHEMICAL NAME :: Phenol, 4,4'-(2-pyridylmethylene)di-

CAS REGISTRY NUMBER :: 603-41-8

BEILSTEIN REFERENCE NO. :: 0212040

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H15-N-O2

MOLECULAR WEIGHT :: 277.34

WISWESSER LINE NOTATION :: T6NJ BYR DQ&R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8550 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken, Japan) V.1- 1950- Volume(issue)/page/year: 28,258,1977

4,4’-(2-吡啶甲基)双酚安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport