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依布硒

依布硒用途

Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。

依布硒名称

[ CAS 号 ]:
60940-34-3

[ 中文名 ]:
依布硒

[ 英文名 ]:
Ebselen

[中文别名 ]:

[英文别名 ]:

2-Phenyl-1,2-benzoselenazol-3(2H)-one
1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-
Ebselenum
2-phenyl-1,2-benzoselenazol-3-one
Harmokisane
Ebselen
MFCD00210937
Ebseleno
Ebselene

依布硒生物活性

[ 描述 ]:

Ebselen是HIV-1复制的小分子抑制剂, 是一种抗氧化药物。

[ 相关类别 ]:

信号通路 >> 自噬 >> 自噬

信号通路 >> 抗感染 >> HIV

研究领域 >> 炎症/免疫

[参考文献]

[1]. Thenin-Houssier S, et al. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208.

[2]. Singh N, et al. A safe lithium mimetic for bipolar disorder. Nat Commun. 2013;4:1332. doi: 10.1038/ncomms2320.

[相关活性小分子]

依布硒物理化学性质

[ 沸点 ]:
402.8±28.0 °C at 760 mmHg

[ 熔点 ]:
178-181 °C

[ 分子式 ]:
C₁₃H₉NOSe

[ 分子量 ]:
274.177

[ 闪点 ]:
197.4±24.0 °C

[ 精确质量 ]:
274.984924

[ PSA ]:
22.00000

[ LogP ]:
2.04770

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 储存条件 ]:
2-8°C

依布硒MSDS

详细MSDS(安全技术说明书)

依布硒毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DE4140750

CHEMICAL NAME :: 1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-

CAS REGISTRY NUMBER :: 60940-34-3

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H9-N-O-Se

MOLECULAR WEIGHT :: 274.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0044971

依布硒安全信息

[ 符号 ]:

GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H331-H373-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/25;R33;R50/53

[ 安全声明 (欧洲) ]:
S20/21-S28-S45-S60-S61-S28A

[ 危险品运输编码 ]:
UN 3283 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DE4140750

[ 海关编码 ]:
2927000090

依布硒制备

1. 2,2’-二硒化二苯甲酸的制备

在反应瓶中加入KOH7.1g(0.13mol)、水18ml和85%水合肼3.2g(0.05mol),于60~70ºC搅拌均匀后分批加入硒粉10g(0.13mol),于70ºC搅拌反应1h.室温下加入由2-氨基苯甲酸17.3g(0.13mol)和亚硝酸钠11.1g(0.16mol)制得的重氮盐溶液.加毕,于60ºC搅拌反应2h.降至室温,用6mol/L盐酸调至pH<1,过滤,滤饼水洗后得红褐色固体.转至1mol/LNa2CO3溶液中,煮沸后滤除不溶物,用1mol/L盐酸调至pH<1,过滤,滤饼水洗后抽干,干燥,得淡黄色固体2,2’-二硒化二苯甲酸22.8g,收率90.1%,mp295~296 ºC.

2. 2-氯硒苯甲酰氯的制备

在反应瓶中加入2,2’-二硒化二苯甲酸6.0g(0.02mol)和SOCl2,剩余物用正己烷重结晶,得浅黄色固体2-氯硒苯甲酰氯6.25g,收率82%,mp63~64ºC.

3. 依布硒的合成

在反应瓶中加入苯胺3ml(0.03mol)和乙醚30ml,搅拌下滴加2-氯硒苯甲酰氯[3.0g(0.01mol)]的乙醚(40ml)溶液,滴加过程控制温度不超过室温(一般25 ºC).加毕,搅拌3h.减压蒸除溶剂,剩余物用快速柱色谱分离[硅胶G,流动相为乙酸乙酯/氯仿(1:2)].蒸除溶剂后得淡黄色固体依布硒3.0g,收率92.6%,mp179~180 ºC.

依布硒海关

[ 海关编码 ]: 2927000090

[ 中文概述 ]:
2927000090 其他重氮化合物、偶氮化合物等（包括氧化偶氮化合物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

依布硒文献

Role of reactive oxygen species in transforming growth factor beta1-induced alpha smooth-muscle actin and collagen production in nasal polyp-derived fibroblasts.

Int. Arch. Allergy Immunol. 159(3) , 278-86, (2012)

Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiati...

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

J. Exp. Med. 212(4) , 555-68, (2015)

The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its re...

Reactive oxygen species are involved in BMP-induced dendritic growth in cultured rat sympathetic neurons.

Mol. Cell. Neurosci. 67 , 116-25, (2015)

Previous studies have shown that bone morphogenetic proteins (BMPs) promote dendritic growth in sympathetic neurons; however, the downstream signaling molecules that mediate the dendrite promoting act...

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依布硒