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4-羟基喹啉

4-羟基喹啉用途

4-喹诺酮(Kynurine)是一种喹啉衍生物。Kynurine途径调节色氨酸代谢并参与神经保护作用。Kynurine通过抑制抗肿瘤免疫来促进肿瘤细胞存活和运动[1][2]。

4-羟基喹啉名称

[ CAS 号 ]:
611-36-9

[ 中文名 ]:
4-羟基喹啉

[ 英文名 ]:
4-quinolone

[中文别名 ]:

[英文别名 ]:

4-Quinolinol
Chinolin-4-ol
p-hydroxyquinoline
4-quinolone
4(1H)-QUINOLINONE
Chinolin-4(1H)-on
Quinolin-4(1H)-one
quinolin-4-one
1,4-Dihydroquinoline-4-one
HYDROXYQUINOLINE,4

4-羟基喹啉生物活性

[ 描述 ]:

4-喹诺酮(Kynurine)是一种喹啉衍生物。Kynurine途径调节色氨酸代谢并参与神经保护作用。Kynurine通过抑制抗肿瘤免疫来促进肿瘤细胞存活和运动[1][2]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 神经疾病

[体外研究]

4-喹诺酮(Kynurine)通过以自分泌/旁分泌方式抑制AhR的抗肿瘤免疫反应,促进肿瘤细胞存活和运动。该系统在人脑肿瘤中特别活跃,其中AhR的激活增强了TDO的表达,从而产生更多的kynurine和kynurinic酸。在健康的人脑中,TDO的水平非常低,而在人脑肿瘤中,随着恶性程度的增加,TDO蛋白的水平增加[3]。

[参考文献]

[1]. Pellicciari R, et al. Modulation of the kynurine pathway of tryptophan metabolism in search for neuroprotective agents. Focus on kynurenine-3-hydroxylase. Adv Exp Med Biol. 2003;527:621-8.

[2]. Marija Pinne, et al. Cytochrome P450 Gene Regulation: Reporter Assays to Assess Aryl Hydrocarbon Receptor (HLHE76, AhR) Activation and Antagonism. Cytochrome P450. pp 157-174.

[3]. Opitz CA, et al. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature. 2011 Oct 5;478(7368):197-203.

4-羟基喹啉物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
313.0±15.0 °C at 760 mmHg

[ 熔点 ]:
200-202 °C(lit.)

[ 分子式 ]:
C₉H₇NO

[ 分子量 ]:
145.158

[ 闪点 ]:
143.1±20.4 °C

[ 精确质量 ]:
145.052765

[ PSA ]:
33.12000

[ LogP ]:
2.45

[ 外观性状 ]:
淡黄色和灰白色晶体粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.691

[ 储存条件 ]:
存放于惰性气体之中;避免光,空气

[ 水溶解性 ]:
可溶于：甲醇

4-羟基喹啉MSDS

4-羟基喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC4070000

CHEMICAL NAME :: 4-Quinolinol

CAS REGISTRY NUMBER :: 611-36-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H7-N-O

MOLECULAR WEIGHT :: 145.17

4-羟基喹啉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
VC4070000

[ 海关编码 ]:
2933499090

4-羟基喹啉合成路线

4-羟基喹啉上下游产品

4-羟基喹啉上游产品

4-羟基喹啉下游产品

4-羟基喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

4-羟基喹啉文献

Synergistic antidepressant-like effect of ferulic acid in combination with piperine: involvement of monoaminergic system.

Metab. Brain Dis. 30 , 1505-14, (2015)

The lifetime prevalence rate for major depressive disorder (MDD) is approximately 17 % for most developed countries around the world. Dietary polyphenols are currently used as an adjuvant therapy to a...

Evolution from a natural flavones nucleus to obtain 2-(4-Propoxyphenyl)quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump.

J. Med. Chem. 54 , 5722-36, (2011)

Overexpression of efflux pumps is an important mechanism by which bacteria evade the effects of substrate antimicrobial agents. Inhibition of such pumps is a promising strategy to circumvent this resi...

Antioxidant properties of 4-quinolones and structurally related flavones.

Bioorg. Med. Chem. 20 , 809-18, (2012)

Neurodegenerative disorders are frequently associated with increased oxidative damage to the brain as a result of free radicals produced by cellular respiration. The onset and progression of neurodege...

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