曲西立滨磷酸酯

曲西立滨磷酸酯用途

Triciribine phosphate (TCN-P) 通过变构机制抑制酰胺磷酸核糖基转移酶,影响嘌呤从头生物合成的第一个关键步骤。Triciribine phosphate 还抑制 IMP 脱氢酶,这是鸟苷核苷酸合成的第一个关键步骤。Triciribine phosphate 不影响连接酶活性。

曲西立滨磷酸酯名称

[ CAS 号 ]:
61966-08-3

[ 中文名 ]:
曲西立滨磷酸酯

[ 英文名 ]:
Phosphate Salt of Tricyclic Nucleoside

[中文别名 ]:

曲西立滨磷酸酯

[英文别名 ]:

Pentaazaacenaphthylene-5' phosphate ester
Phosphate Salt of Tricyclic Nucleoside
Triciribine phosphate (USAN)
VQD-002
TCN-P

曲西立滨磷酸酯生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 代谢疾病

信号通路 >> 跨膜转运 >> ATP合成酶

[参考文献]

[1]. E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22.

曲西立滨磷酸酯物理化学性质

[ 密度 ]:
2.2±0.1 g/cm3

[ 沸点 ]:
832.8±75.0 °C at 760 mmHg

[ 分子式 ]:
C₁₃H₁₇N₆O₇P

[ 分子量 ]:
400.28

[ 闪点 ]:
457.4±37.1 °C

[ 精确质量 ]:
400.089630

[ PSA ]:
200.81000

[ LogP ]:
-2.83

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.925

曲西立滨磷酸酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RY8450000

CHEMICAL NAME :: 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D- ribofuranosyl)-

CAS REGISTRY NUMBER :: 61966-08-3

LAST UPDATED :: 198605

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H17-N6-O7-P

MOLECULAR WEIGHT :: 400.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 193 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 109 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986