异麦芽酮糖醇

异麦芽酮糖醇用途

Isomalt (Palatinitol) 是一种耐受性良好,无毒的多元醇和蛋白质稳定的赋形剂,在冷冻干燥过程中可适度稳定乳酸脱氢酶 (LDH),并在储存期间表现更好。 Isomalt 传统上在食品工业中用作甜味剂,并在制药中用作压片赋形剂。

异麦芽酮糖醇名称

[ CAS 号 ]:
64519-82-0

[ 中文名 ]:
异麦芽酮糖醇

[ 英文名 ]:
glucosylmannitol

[中文别名 ]:

益寿糖

[英文别名 ]:

1-O-α-D-Glucopyranosyl-D-mannitol
Plaltinitol
PALATINOL
ISOMALT USP
MFCD00190708
PALATINIT
hydrogenated isomaltulose
glucosylmannitol
Isomaltitol
EINECS 203-252-1

异麦芽酮糖醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 乳酸脱氢酶

研究领域 >> 代谢疾病

[体内研究]

研究了口服异麦芽作为饲料的一部分对动物的慢性毒性,发现异麦芽是一种安全的物质。它没有影响动物的死亡率,也没有致癌或对生育、生殖性能或发育产生不利影响的证据[1]。

[参考文献]

[1]. Tuderman AK, et al. Isomalt and its diastereomer mixtures as stabilizing excipients with freeze-dried lactate dehydrogenase. Int J Pharm. 2018 Mar 1;538(1-2):287-295.

异麦芽酮糖醇物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
788.5±60.0 °C at 760 mmHg

[ 熔点 ]:
215-217°C

[ 分子式 ]:
C₁₂H₂₄O₁₁

[ 分子量 ]:
344.312

[ 闪点 ]:
430.7±32.9 °C

[ 精确质量 ]:
344.131866

[ PSA ]:
401.06000

[ LogP ]:
-5.72

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±6.2 mmHg at 25°C

[ 折射率 ]:
1.634

[ 储存条件 ]:
2-8°C

异麦芽酮糖醇MSDS

详细MSDS(安全技术说明书)

异麦芽酮糖醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ4394500

CHEMICAL NAME :: D-Glucitol, 6-O-alpha-D-glucopyranosyl-, mixed with 1-O-alpha-D-glucopyranosyl-D-mannitol

CAS REGISTRY NUMBER :: 64519-82-0

LAST UPDATED :: 199312

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H24-O11.C12-H24-O11

MOLECULAR WEIGHT :: 688.72

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 125 mg/kg

SEX/DURATION :: female 5 day(s) pre-mating female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 27,631,1989

异麦芽酮糖醇安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
22-26-36/37/39-45

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
LZ4394500

[ 海关编码 ]:
2940000000

异麦芽酮糖醇制备

由蔗糖用酶法转化为异麦芽酮糖（帕拉金糖）后，催化加氢，经浓缩、结晶、分离而得。

异麦芽酮糖醇海关

[ 海关编码 ]: 2940000000

异麦芽酮糖醇文献

Assessment of isomalt for colon-specific delivery and its comparison with lactulose.

AAPS PharmSciTech 14(1) , 53-9, (2013)

Lactulose is used as a triggering substance in a unique colon-specific delivery technology called CODESTM. Colonic microflora degrades lactulose and forms short-chain fatty acids to activate the CODES...

Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers.

Br. J. Nutr. 95(1) , 40-50, (2006)

Due to its low digestibility in the small intestine, a major fraction of the polyol isomalt reaches the colon. However, little is known about effects on the intestinal microflora. During two 4-week pe...

Effects of isomalt consumption on gastrointestinal and metabolic parameters in healthy volunteers.

Br. J. Nutr. 94(4) , 575-81, (2005)

The polyol isomalt (Palatinit) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined ...

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