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胞嘧啶核苷

胞嘧啶核苷用途

Cytidine是一种核苷分子。

胞嘧啶核苷名称

[ CAS 号 ]:
65-46-3

[ 中文名 ]:
胞苷

[ 英文名 ]:
Cytidine

[中文别名 ]:

[英文别名 ]:

EINECS 200-610-9
2(1H)-Pyrimidinone, 4-amino-1-β-D-ribofuranosyl-
1-β-D-Ribofuranosylcytosine
4-Amino-1-β-δ-ribofuranosyl-2(1H)-pyrimidinone
4-Amino-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-on
MFCD02181091
Cytidine
4-Amino-1-b-D-ribofuranosyl-2(1H)-pyrimidinone
Cyd
Cytidin

胞嘧啶核苷生物活性

[ 描述 ]:

Cytidine是一种核苷分子。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

天然产物 >> 生物碱

研究领域 >> 癌症

[ 靶点 ]

Human Endogenous Metabolite

[参考文献]

[1]. Jonas DA, et al. Safety considerations of DNA in food. Ann Nutr Metab. 2001;45(6):235-54.

[2]. Wurtman RJ, et al. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem Pharmacol. 2000 Oct 1;60(7):989-92.

[相关活性小分子]

胞嘧啶核苷物理化学性质

[ 密度 ]:
1.9±0.1 g/cm3

[ 沸点 ]:
529.7±60.0 °C at 760 mmHg

[ 熔点 ]:
210-220 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₁₃N₃O₅

[ 分子量 ]:
243.217

[ 闪点 ]:
274.1±32.9 °C

[ 精确质量 ]:
243.085526

[ PSA ]:
130.83000

[ LogP ]:
-1.78

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 蒸汽压 ]:
0.0±3.2 mmHg at 25°C

[ 折射率 ]:
1.756

[ 储存条件 ]:
存放于惰性气体之中;避免空气,湿气 (吸湿)

[ 水溶解性 ]:
SOLUBLE

胞嘧啶核苷MSDS

胞嘧啶核苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7370000

CHEMICAL NAME :: 2(1H)-Pyrimidinone, 4-amino-1-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 65-46-3

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H13-N3-O5

MOLECULAR WEIGHT :: 243.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 150 umol/L

REFERENCE :: PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9990 No. of Facilities: 35 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 115 (estimated) No. of Female Employees: 64 (estimated)

胞嘧啶核苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
F+

[ 风险声明 (欧洲) ]:
R68

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
UW7370000

[ 海关编码 ]:
2934999090

胞嘧啶核苷合成路线

胞嘧啶核苷上下游产品

胞嘧啶核苷上游产品

胞嘧啶核苷下游产品

胞嘧啶核苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

胞嘧啶核苷文献

Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants.

Nat. Commun. 6 , 6513, (2015)

Complex quantitative traits, like size and behaviour, are a pervasive feature of natural populations. Quantitative trait variation is the product of both genetic and environmental factors, yet little ...

The contribution of CMP kinase to the efficiency of DNA repair.

Cell Cycle 14(3) , 354-63, (2015)

Cellular supply of deoxynucleoside triphosphates (dNTPs) is crucial for DNA replication and repair. In this study, we investigated the role of CMP/UMP kinase (CMPK), an enzyme catalyzes CDP formation,...

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier.

Nat. Commun. 6 , 6716, (2015)

Brain metastasis is an important cause of mortality in breast cancer patients. A key event during brain metastasis is the migration of cancer cells through blood-brain barrier (BBB). However, the mole...

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