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胞嘧啶

胞嘧啶用途

6-Aminopyrimidin-2(1H)-one 是属于嘧啶酮的有机化合物。

胞嘧啶名称

[ CAS 号 ]:
71-30-7

[ 中文名 ]:
胞嘧啶

[ 英文名 ]:
cytosine

[中文别名 ]:

[英文别名 ]:

MFCD00006034
Cytosin
EINECS 200-749-5
Cytosinimine
Cytosine
4-aminopyrimidin-2-one
Cyt
Lamivudine Impurity 5
6-Aminopyrimidin-2(1H)-one

胞嘧啶生物活性

[ 描述 ]:

6-Aminopyrimidin-2(1H)-one 是属于嘧啶酮的有机化合物。

[ 相关类别 ]:

天然产物 >> 醌类

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

胞嘧啶物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
445.8ºC at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₄H₅N₃O

[ 分子量 ]:
111.102

[ 闪点 ]:
223.4ºC

[ 精确质量 ]:
111.043259

[ PSA ]:
71.77000

[ LogP ]:
-2.29

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.689

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
soluble

胞嘧啶MSDS

胞嘧啶毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW7350150

CHEMICAL NAME :: 2(1H)-Pyrimidinone, 4-amino-

CAS REGISTRY NUMBER :: 71-30-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C4-H5-N3-O

MOLECULAR WEIGHT :: 111.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2222 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 207,504,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3859 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 312 (estimated) No. of Female Employees: 303 (estimated)

胞嘧啶安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
UW7350150

[ 海关编码 ]:
2933599090

胞嘧啶合成路线

胞嘧啶上下游产品

胞嘧啶上游产品

胞嘧啶下游产品

胞嘧啶制备

可由二巯基尿嘧啶、浓氨水和氯乙酸为原料合成制得。

胞嘧啶海关

[ 海关编码 ]: 2933591000

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
HS:2933591000 4-aminopyrimidin-2(1h)-one VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

胞嘧啶文献

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J. Bacteriol. 197(5) , 819-32, (2015)

Clostridium difficile is an anaerobic Gram-positive bacterium that causes intestinal infections with symptoms ranging from mild diarrhea to fulminant colitis. Cyclic diguanosine monophosphate (c-di-GM...

Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expression during cell state transitions between pluripotency and differentiation.

Mol. Cell. Biol. 35(6) , 1026-42, (2015)

The Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine and further oxidized products. Tet1 and Tet2 are highly expressed in mouse pluripotent cells and d...

ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.

Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...

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胞嘧啶