氨来呫诺
氨来呫诺用途
氨来呫诺名称
[ CAS 号 ]:
68302-57-8
[ 中文名 ]:
氨来占诺
[ 英文名 ]:
Amlexanox
[中文别名 ]:
[英文别名 ]:
- Amlexanoxum
- Amlenanox
- Amlexanox
- Amlexanoxo
- Elics
- Amoxanox
- Solfa
- MFCD00864790
- amlexanoxum [INN_la]
- Aphthasol
氨来呫诺生物活性
[ 描述 ]:
[ 相关类别 ]:
[ 靶点 ]
IKKε:1-2 μM (IC50)
TBK1:1-2 μM (IC50)
[体外研究]
[体内研究]
[激酶实验]
[细胞实验]
[动物实验]
[参考文献]
[相关活性小分子]
氨来呫诺物理化学性质
[ 密度 ]:
1.4±0.1 g/cm3
[ 沸点 ]:
570.0±50.0 °C at 760 mmHg
[ 熔点 ]:
>3000C
[ 分子式 ]:
C16H14N2O4
[ 分子量 ]:
298.293
[ 闪点 ]:
298.5±30.1 °C
[ 精确质量 ]:
298.095367
[ PSA ]:
106.42000
[ LogP ]:
3.74
[ 外观性状 ]:
白色结晶固体
[ 蒸汽压 ]:
0.0±1.6 mmHg at 25°C
[ 折射率 ]:
1.669
[ 储存条件 ]:
-20°C Freezer
氨来呫诺MSDS
氨来呫诺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DJ3102000
- CHEMICAL NAME :
- 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic acid, 2-amino-7-(1-methylethyl)-5-oxo-
- CAS REGISTRY NUMBER :
- 68302-57-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C16-H14-N2-O4
- MOLECULAR WEIGHT :
- 298.32
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,6405,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,6405,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,6405,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2320 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,6405,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,6405,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3310 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,6405,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 gm/kg/5W-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,4843,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 54600 mg/kg/26W-C
- TOXIC EFFECTS :
- Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,6411,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3500 mg/kg/5W-C
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 13,7123,1985
氨来呫诺安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H302
[ 警示性声明 ]:
P301 + P312 + P330
[ 危害码 (欧洲) ]:
Xn,Xi
[ 风险声明 (欧洲) ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin .
[ 安全声明 (欧洲) ]:
S26
[ 危险品运输编码 ]:
NONH for all modes of transport
[ WGK德国 ]:
3
[ RTECS号 ]:
XZ3012000
[ 海关编码 ]:
2934999090
氨来呫诺合成路线
氨来呫诺上下游产品
氨来呫诺上游产品
氨来呫诺下游产品
氨来呫诺制备
3-氰基6-异丙基苯并吡喃酮(I)在含吗啉和二甲基甲酰胺的水溶液中,在60℃加热反应,得到化合物(Ⅱ)。再和丙二酸单乙酯酰胺缩合环合,然后水解得到氨来咕诺。
氨来呫诺海关
[ 海关编码 ]: 2934999090
[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
氨来呫诺文献
J. Interferon Cytokine Res. 35(3) , 143-56, (2015)
Hydroxychloroquine (HCQ) is an antimalarial drug also used in treating autoimmune diseases. Its antiviral activity was demonstrated in restricting HIV infection in vitro; however, the clinical implica...
Role of G Protein-Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization.Mol. Pharmacol. 88 , 347-56, (2015)
There is ongoing debate about the role of G protein-coupled receptor kinases (GRKs) in agonist-induced desensitization of the μ-opioid receptor (MOPr) in brain neurons. In the present paper, we have u...
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.Nat. Commun. 6 , 6074, (2015)
Development of an immune or autoimmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral tissues. Here we show that T-cell-specific ablation of the kinase T...
相关化工产品/化学物质:
相关药品:
推荐生产厂家/供应商:
公司名:上海化源世纪贸易有限公司
区域:上海市普陀区
价格:
联系人:徐经理
产品详情:氨来占诺
公司名:上海源溪生物科技有限公司
区域:上海市浦东新区
价格:
¥需询单/1g
联系人:赖经理
产品详情:AA-673(Amlexanox)
公司名:上海脉铂医药科技有限公司
区域:上海市嘉定区
价格:
¥3811.0/5g
¥951.0/1g
¥626.0/500mg
¥需询单/1g
联系人:李先生
产品详情:Amlexanox
公司名:上海创赛科技有限公司
区域:上海市嘉定区
价格:
¥97.0/250mg
¥168.0/1g
¥543.0/5g
¥1956.0/25g
联系人:夏言
产品详情:[Perfemiker]氨来占诺,98%
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥150.9/1g
¥68.9/250mg
¥205.9/1ml
¥513.9/5g
联系人:阿拉丁
产品详情:氨来呫诺
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氨来呫诺相关知识
2018-10-30 14:16:55
氨来呫诺是一种抗口疮性溃疡药物。氨来呫诺抑制肥大细胞,中性粒细胞和单核细胞中炎症介质(包括白三烯和组胺)的合成和释放。氨来呫诺还可作为白三烯D4拮抗剂和磷酸二酯酶抑制剂。氨来呫诺减少溃疡愈合的时间以及与溃疡相关的疼痛。一、氨来呫诺的生物活性详解:1)体外活性氨来呫诺可增加3T3-L1脂肪细胞中Se...
相关化合物
【氨来呫诺】化源网提供氨来呫诺CAS号68302-57-8,氨来呫诺MSDS及其说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。CAS号查询氨来呫诺上化源网,专业又轻松。>>电脑版:氨来呫诺
标题:氨来呫诺_MSDS_用途_密度_氨来呫诺CAS号【68302-57-8】_化源网 地址:https://www.chemsrc.com/amp/cas/68302-57-8_895207.html