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藜芦定

藜芦定用途

Veratridine (3-Veratroylveracevine) 是一种来自百合科的植物的生物碱,是一种钠通道激动剂。Veratridine 可抑制 Nav1.7 的峰值电流,IC50 为 18.39 µM。

藜芦定名称

[ CAS 号 ]:
71-62-5

[ 中文名 ]:
藜芦定

[ 英文名 ]:
Veratridine

[中文别名 ]:

藜芦定

[英文别名 ]:

Metergoline
,4alpha,16beta)
EINECS 200-758-4
Veracevine,veratrate
ybenzoate)
VERATRIDINE
3-VERATROYLVERACEVINE
MFCD00082515

藜芦定生物活性

[ 描述 ]:

Veratridine (3-Veratroylveracevine) 是一种来自百合科的植物的生物碱,是一种钠通道激动剂。Veratridine 可抑制 Nav1.7 的峰值电流,IC50 为 18.39 µM。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> 钠通道

研究领域 >> 神经疾病

[参考文献]

[1]. Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724.

藜芦定物理化学性质

[ 密度 ]:
1.45 g/cm3

[ 沸点 ]:
814.5ºC at 760 mmHg

[ 熔点 ]:
180ºC

[ 分子式 ]:
C₃₆H₅₁NO₁₁

[ 分子量 ]:
673.79000

[ 闪点 ]:
446.4ºC

[ 精确质量 ]:
673.34600

[ PSA ]:
178.61000

[ LogP ]:
1.29390

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.663

[ 储存条件 ]:
库房低温,通风,干燥,与食品原料分开存放

藜芦定毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YX5600000

CHEMICAL NAME :: Veratridine

CAS REGISTRY NUMBER :: 71-62-5

BEILSTEIN REFERENCE NO. :: 0078875

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C36-H51-N-O11

MOLECULAR WEIGHT :: 673.88

WISWESSER LINE NOTATION :: T J6 H6 E6 D5665/TC& 3ATU C& ON TX C&OTJ EQ GQ HQ IQ I1 M1 RQ U1 A&OVR CO1 DO1& B&Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 78,238,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1350 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 76,847,1951

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,89,1955

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Cardiac - arrhythmias (including changes in conduction)

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 120,412,1957

藜芦定安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300 + H310 + H330-H315-H319-H335-H361-H373-H412

[ 警示性声明 ]:
P260-P262-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P403 + P233

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T+: Very toxic;

[ 风险声明 (欧洲) ]:
R26/27/28

[ 安全声明 (欧洲) ]:
S26;S36/S37/S39;S45

[ 危险品运输编码 ]:
UN 1544 6

[ WGK德国 ]:
2

[ RTECS号 ]:
YX5600000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2929101000

藜芦定合成路线

详细合成路线

藜芦定上下游产品

藜芦定上游产品

藜芦定下游产品

藜芦定海关

[ 海关编码 ]: 2929101000

[ 中文概述 ]:
2929101000. 甲苯二异氰酸酯(TDI). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最低关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 原产地证据文件及编号(例附原产地证书, 原产于日本、韩国、美国、欧盟的

[ Summary ]:
2929101000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:30.0%

藜芦定文献

Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells.

Naunyn Schmiedebergs Arch. Pharmacol. 388 , 1259-69, (2015)

Ikarisoside A is a natural flavonol glycoside derived from plants of the genus Epimedium, which have been used in Traditional Chinese Medicine as tonics, antirheumatics, and aphrodisiacs. Here, we rep...

Contribution to the risk characterization of ciguatoxins: LOAEL estimated from eight ciguatera fish poisoning events in Guadeloupe (French West Indies).

Environ. Res. 143 , 100-8, (2015)

From 2010 to 2012, 35 ciguatera fish poisoning (CFP) events involving 87 individuals who consumed locally-caught fish were reported in Guadeloupe (French West Indies). For 12 of these events, the pres...

Voltage-activated calcium channels involved in veratridine-evoked [3H]dopamine release in rat striatal slices.

Neuropharmacology 37 , 973-982, (1998)

The present study explored the role of different sub-types of voltage-activated Ca2+ channels (VACCs) in mediating veratridine-evoked [3H]dopamine (DA) release from rat striatal slices. The release of...

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藜芦定