红海海绵素 B

红海海绵素 B用途

Latrunculin B是一种抗菌海洋生物碱,是一种肌动蛋白聚合抑制剂。Latrunculin B调节肺静脉电生理特性并减轻牵张诱发的心律失常[1][2]。抗真菌和抗原虫活性。

红海海绵素 B名称

[ 英文名 ]:
2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)-

[英文别名 ]:

LATRUNCULIN B
LATRUNCULIN B,LATRUNCULIA MAGNIFICA
MFCD00270879
LAT-B
LatrunculinBfromLutrunculiamagnifica

红海海绵素 B生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

[体外研究]

Latrunculin B显示对HeLa细胞的生长抑制,IC50值为1.4μM[1]。Latrunculin B调节肺静脉心肌细胞的电生理特性和心律失常发生。在肺静脉(PV)制剂中,Latrunculin B(100 nM)可将自发电活动降低16±4%。Latrunculin B(100 nM)降低PV心肌细胞的晚期Na+电流、L型Ca2+电流、Na+/Ca2+交换电流和拉伸激活的BKCa电流。latrunculinb降低了分离的PV心肌细胞的瞬时外向K+电流和超快速延迟整流K+电流,但增加了延迟整流K+电流。latrunculinb(100nm)降低PV心肌细胞内瞬时钙离子含量和肌浆网钙离子含量。Latrunculin B减弱拉伸引起的自发电活动和触发活动的增加[2]。

[参考文献]

[1]. Diaa T A Youssef, et al. Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5( 3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica. Mar Drugs. 2021 Apr 12;19(4):214.

[2]. Yen-Yu Lu, et al. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32.

红海海绵素 B物理化学性质

[ 分子式 ]:
C₂₀H₂₉NO₅S

[ 分子量 ]:
395.51300

[ 精确质量 ]:
395.17700

[ PSA ]:
110.16000

[ LogP ]:
3.63220

[ 外观性状 ]:
黄色固体

[ 储存条件 ]:
20°C

红海海绵素 B安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

红海海绵素 B合成路线

详细合成路线

红海海绵素 B上下游产品

红海海绵素 B上游产品

红海海绵素 B下游产品

红海海绵素 B文献

Arabidopsis dynamin-related proteins, DRP2A and DRP2B, function coordinately in post-Golgi trafficking.

Biochem. Biophys. Res. Commun. 456(1) , 238-44, (2015)

Dynamin-related proteins (DRPs) are large GTPases involved in a wide range of cellular membrane remodeling processes. In Arabidopsis thaliana, two paralogous land plant-specific type DRPs, DRP2A and D...

Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis.

J. Cell Physiol. 229(3) , 362-73, (2014)

Cancer cells typically demonstrate altered morphology during the various stages of disease progression as well as metastasis. While much is known about how altered cell morphology in cancer is a resul...

The formation of cortical actin arrays in human trabecular meshwork cells in response to cytoskeletal disruption.

Exp. Cell Res. 328(1) , 164-71, (2014)

The cytoskeleton of human trabecular meshwork (HTM) cells is known to be altered in glaucoma and has been hypothesized to reduce outflow facility through contracting the HTM tissue. Latrunculin B (Lat...

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