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甲琥胺

甲琥胺用途

甲磺酰亚胺是一种抗惊厥剂。甲磺脒对小发作、精神运动和局灶性运动发作有效[1]。

甲琥胺名称

[ CAS 号 ]:
77-41-8

[ 中文名 ]:
甲琥胺

[ 英文名 ]:
methsuximide

[中文别名 ]:

[英文别名 ]:

Celontin
1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dion
1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione
mesuximid
Mesuximide
Mesuximida
Metsuccimide
Petinutin
methsuximide
Methsuximid

甲琥胺生物活性

[ 描述 ]:

甲磺酰亚胺是一种抗惊厥剂。甲磺脒对小发作、精神运动和局灶性运动发作有效[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. MARY LOUISE SCHOLL, et al. Celontin - a New Anticonvulsant.

甲琥胺物理化学性质

[ 密度 ]:
1.59g/cm3

[ 沸点 ]:
489.2ºC at 760 mmHg

[ 熔点 ]:
52-53°

[ 分子式 ]:
C₁₂H₁₃NO₂

[ 分子量 ]:
203.23700

[ 闪点 ]:
191.7ºC

[ 精确质量 ]:
203.09500

[ PSA ]:
37.38000

[ LogP ]:
1.27090

[ 折射率 ]:
1.692

[ 储存条件 ]:
Refrigerator

甲琥胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN2625000

CHEMICAL NAME :: Succinimide, N,2-dimethyl-2-phenyl-

CAS REGISTRY NUMBER :: 77-41-8

BEILSTEIN REFERENCE NO. :: 0168315

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H13-N-O2

MOLECULAR WEIGHT :: 203.26

WISWESSER LINE NOTATION :: T5VNVTJ B1 D1 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 6,740,1954 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 1006 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6158 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 876 (estimated) No. of Female Employees: 408 (estimated)

甲琥胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H412

[ 警示性声明 ]:
P301 + P312 + P330

[ 危险品运输编码 ]:
NONH for all modes of transport

甲琥胺

甲琥胺用途

甲琥胺名称

甲琥胺生物活性

甲琥胺物理化学性质

甲琥胺毒性和生态

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

甲琥胺安全信息

甲琥胺合成路线

详细合成路线

甲琥胺上下游产品

甲琥胺上游产品

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