77-41-8

• 常用中文名：甲琥胺
• 常用英文名：methsuximide
• CAS号：77-41-8
• 分子式：C₁₂H₁₃NO₂
• 分子量：203.23700
• 相关类别： 原料药 神经系统用药 抗癫痫及抗惊厥药
• 发布时间：2018-05-14 08:00:00
• 更新时间：2024-01-05 10:37:46
• 甲磺酰亚胺是一种抗惊厥剂。甲磺脒对小发作、精神运动和局灶性运动发作有效[1]。

名称

• 中文名: 甲琥胺
• 英文名: 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
• 中文别名: 锡郎丁; 1,3-二甲基-3-苯基-5-吡咯烷二酮
• 英文别名: Celontin; 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dion; 1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione; mesuximid; Mesuximide; Mesuximida; Metsuccimide; Petinutin; methsuximide; Methsuximid; Mesuximidum

物化性质

• 密度: 1.59g/cm3
• 沸点: 489.2ºC at 760 mmHg
• 熔点: 52-53°
• 分子式: C₁₂H₁₃NO₂
• 分子量: 203.23700
• 闪点: 191.7ºC
• 精确质量: 203.09500
• PSA: 37.38000
• LogP: 1.27090
• 折射率: 1.692
• 储存条件: Refrigerator

生物活性

• 描述: 甲磺酰亚胺是一种抗惊厥剂。甲磺脒对小发作、精神运动和局灶性运动发作有效[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. MARY LOUISE SCHOLL, et al. Celontin - a New Anticonvulsant.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WN2625000 CHEMICAL NAME : Succinimide, N,2-dimethyl-2-phenyl- CAS REGISTRY NUMBER : 77-41-8 BEILSTEIN REFERENCE NO. : 0168315 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C12-H13-N-O2 MOLECULAR WEIGHT : 203.26 WISWESSER LINE NOTATION : T5VNVTJ B1 D1 DR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 6,740,1954 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported DOSE : 1006 mg/kg SEX/DURATION : female 8-10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system REFERENCE : FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6158 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 876 (estimated) No. of Female Employees: 408 (estimated)

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302-H412
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport

合成路线

14231-67-5 74-89-5 ~% 77-41-8

文献：Vystrcil; Cerny Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 804,807 Show Details Miller; Long Journal of the American Chemical Society, 1951 , vol. 73, p. 4895,4897

上下游产品

上游产品  2
14231-67-5 74-89-5
下游产品  1
39122-23-1