53-46-3

• 常用中文名：溴甲胺太林
• 常用英文名：Methantheline Bromide
• CAS号：53-46-3
• 分子式：C₂₁H₂₆BrNO₃
• 分子量：420.34000
• 相关类别： 生物化工 植物提取物
• 发布时间：2018-07-23 18:02:07
• 更新时间：2024-01-10 03:11:03
• Methantheline Bromide is a synthetic antispasmodic. It is used to relieve cramps or spasms of the stomach, intestines, and bladder. Methantheline is used to treat intestine or stomach ulcers (peptic ulcer disease), intestine problems, pancreatitis, gastritis, biliary dyskinesia, pylorosplasm, or urinary problems.

名称

• 中文名: 溴甲胺太林
• 英文名: methantheline bromide (200 mg)
• 英文别名: asabaine; Methanthelinium bromide; mtb51; diethyl-methyl-[2-(xanthene-9-carbonyloxy)-ethyl]-ammonium,bromide; sc2910; ulcine; N,N-diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]-ethanaminium; methanthelinium bromide; banthin; Diaethyl-methyl-[2-(xanthen-9-carbonyloxy)-aethyl]-ammonium,Bromid; avagal; Ulcine Bromide; methantheline bromide; doladene; metaxan; banthine; vagamin

物化性质

• 分子式: C₂₁H₂₆BrNO₃
• 分子量: 420.34000
• 精确质量: 419.11000
• PSA: 35.53000
• LogP: 0.95780

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : BP7632500 CHEMICAL NAME : Ammonium, diethyl(2-hydroxyethyl)methyl-, bromide, xanthene-9-carboxylate CAS REGISTRY NUMBER : 53-46-3 LAST UPDATED : 199712 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C21-H26-N-O3.Br MOLECULAR WEIGHT : 420.39 WISWESSER LINE NOTATION : T C666 BO IHJ IVO2K2&2&1 &Q &E HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 78,708,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4800 ug/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,391,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,357,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 46 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 106,141,1952 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,107,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,221,1956 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 460 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,54,1952 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 23 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 78,576,1951 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 7935 mg/kg/95D-I TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Kidney, Ureter, Bladder - interstitial nephritis Related to Chronic Data - death REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,54,1952

安全

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2932999099

合成路线

74-83-9 24539-72-8 ~% 53-46-3

文献：US2659732 , ; DE948333 , ;

82-07-5 ~% 53-46-3

文献：Pharmaceutical Bulletin, , vol. 3, p. 417,420

上下游产品

上游产品  3
74-83-9 24539-72-8 82-07-5
下游产品  0

海关

海关编码	2932999099
中文概述	2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%