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栗精胺

栗精胺用途

Castanospermine可以抑制α- and β-glucosidases的所有形式,特别是glucosidase l.

栗精胺名称

[ CAS 号 ]:
79831-76-8

[ 中文名 ]:
栗精胺

[ 英文名 ]:
Castanospermine

[中文别名 ]:

栗树精胺

[英文别名 ]:

Castanospermine
MFCD00017555

栗精胺生物活性

[ 描述 ]:

Castanospermine可以抑制α- and β-glucosidases的所有形式,特别是glucosidase l.

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

天然产物 >> 生物碱

研究领域 >> 癌症

[参考文献]

[1]. Bryan G, Anthony C et al. The structural basis of the inhibition of human glycosidases by castanospermine analogues. Biochem. J. (1990) 269, 227-231.

[2]. Eisaku Tsujii et al. Nectrisine Is a Potent Inhibitor of a-Glucosidases, Demonstrating Activities Similarly at Enzyme and Cellular Levels. Biochemical and Biophysical Research Communications 220, 459-466 (1996)

[3]. Pili R et al. The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, preventsangiogenesis, and inhibits tumor growth. Cancer Res. 1995 Jul 1;55(13):2920-6.

[相关活性小分子]

栗精胺物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
421.9±45.0 °C at 760 mmHg

[ 熔点 ]:
213-217 °C(lit.)

[ 分子式 ]:
C₈H₁₅NO₄

[ 分子量 ]:
189.209

[ 闪点 ]:
267.6±27.4 °C

[ 精确质量 ]:
189.100113

[ PSA ]:
84.16000

[ LogP ]:
-1.61

[ 蒸汽压 ]:
0.0±2.3 mmHg at 25°C

[ 折射率 ]:
1.647

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
1 M HCl: 20 mg/mL, clear, very faintly yellow

栗精胺MSDS

详细MSDS(安全技术说明书)

栗精胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;Xi: Irritant;

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

栗精胺合成路线

详细合成路线

栗精胺上下游产品

栗精胺上游产品

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栗精胺文献

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栗精胺