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亚精胺

亚精胺用途

【用途一】
抑制神经元NO合成酶(nNOS)。结合并沉淀DNA; 也用于纯化DNA结合蛋白。刺激T4 聚核苷酸激酶活性。

亚精胺名称

[ CAS 号 ]:
124-20-9

[ 中文名 ]:
亚精胺

[ 英文名 ]:
spermidine

[中文别名 ]:

[英文别名 ]:

spermidine
N-(γ-aminopropyl)tetramethylenediamine
N-(3-Aminopropyl)butan-1,4-diamin
N'-(3-aminopropyl)butane-1,4-diamine
Additive Screening
N1-(3-Aminopropyl)butane-1,4-diamine
N-(3-Aminopropyl)-4-aminobutylamine
N-(3-Aminopropyl)butane-1,4-diamine
MFCD00008229
1,4-Butanediamine, N-(3-aminopropyl)-

亚精胺生物活性

[ 描述 ]:

Spermidine 是精胺的前体,从腐胺衍生而来,能够促进细胞膜和核酸的结构稳定。

[ 相关类别 ]:

研究领域 >> 代谢疾病

天然产物 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

亚精胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
246.6±8.0 °C at 760 mmHg

[ 熔点 ]:
23-25 °C

[ 分子式 ]:
C₇H₁₉N₃

[ 分子量 ]:
145.246

[ 闪点 ]:
118.1±22.0 °C

[ 精确质量 ]:
145.157898

[ PSA ]:
64.07000

[ LogP ]:
-0.84

[ 外观性状 ]:
固体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.475

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable, but air-sensitive and very hygroscopic - store under argon. Incompatible with acids, acid chlorides, acid anhydrides, oxidizing agents.

[ 水溶解性 ]:
H2O: 1 M at 20 °C, clear, colorless

亚精胺MSDS

亚精胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ7000000

CHEMICAL NAME :: 1,4-Butanediamine, N-(3-aminopropyl)-

CAS REGISTRY NUMBER :: 124-20-9

BEILSTEIN REFERENCE NO. :: 1698591

LAST UPDATED :: 199706

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C7-H19-N3

MOLECULAR WEIGHT :: 145.29

WISWESSER LINE NOTATION :: Z4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 9504 gm/kg/14D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lung

DOSE/DURATION :: 200 mmol/L

REFERENCE :: IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1959- Volume(issue)/page/year: 9,185,1965

亚精胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
EJ7000000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2921290000

亚精胺合成路线

亚精胺上下游产品

亚精胺上游产品

亚精胺下游产品

亚精胺制备

1. 烟草：OR，27。

亚精胺海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

亚精胺文献

TYLCV-Is movement in planta does not require V2 protein.

Virology 477 , 56-60, (2015)

Tomato yellow leaf curl virus (TYLCV), a major tomato pathogen causing extensive crop losses, is a whitefly-transmitted geminivirus. V2 mutants of TYLCV-Is and related viruses tend to induce symptomle...

Hypoxia reduces MAX expression in endothelial cells by unproductive splicing.

FEBS Lett. 588(24) , 4784-90, (2014)

The MYC-MAX-MXD network is involved in the regulation of cell differentiation and proliferation. Hypoxia affects the expression levels of several members of this network, but changes specific to MAX e...

H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.

J. Endocrinol. 223(3) , 241-53, (2014)

The histamine H4 receptor (HRH4), discovered only 13 years ago, is considered a promising drug target for allergy, inflammation, autoimmune disorders and cancer, as reflected by a steadily growing num...

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亚精胺