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精胺

精胺用途

Spermine 作为一个直接的自由基清除者,能后保护 DNA 免受自由基的攻击。

精胺名称

[ CAS 号 ]:
71-44-3

[ 中文名 ]:
精胺

[ 英文名 ]:
Spermine

[中文别名 ]:

[英文别名 ]:

Spermin
1,4-Butanediamine, N,N-bis(3-aminopropyl)-
MUSCULAMINE HYDROCHLORIDE
EINECS 200-754-2
N,N'-Bis(3-aminopropyl)butane-1,4-diamine
N,N'-Bis(3-aminopropyl)-1,4-butanediamine
N,N'-Bis(3-aminopropyl)butan-1,4-diamin
N,N'-Bis(3-aminopropyl)-1,4-diaminobutane
N,N'-Bis(3-aminopropyl)tetramethylenediamine
Spermine

精胺生物活性

[ 描述 ]:

Spermine 作为一个直接的自由基清除者,能后保护 DNA 免受自由基的攻击。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 代谢疾病

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

生理学相关浓度的精胺抑制ROS诱导的DNA损伤,在1至2mM观察到最大抑制。这些浓度完全在精子生理浓度的估算范围内[1]。

[参考文献]

[1]. Ha HC, et al. The natural polyamine spermine functions directly as a free radical scavenger. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11140-5.

[相关活性小分子]

精胺物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
308.4±0.0 °C at 760 mmHg

[ 熔点 ]:
310-311 °C (dec.)(lit.)

[ 分子式 ]:
C₁₀H₂₆N₄

[ 分子量 ]:
202.340

[ 闪点 ]:
175.6±22.6 °C

[ 精确质量 ]:
202.215744

[ PSA ]:
76.10000

[ LogP ]:
-0.96

[ 外观性状 ]:
白色至略灰白色粉末晶体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.485

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 1 M at 20 °C, clear, colorless

精胺MSDS

精胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ7175000

CHEMICAL NAME :: 1,4-Butanediamine, N,N'-bis(3-aminopropyl)-

CAS REGISTRY NUMBER :: 71-44-3

BEILSTEIN REFERENCE NO. :: 1750791

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H26-N4

MOLECULAR WEIGHT :: 202.40

WISWESSER LINE NOTATION :: Z3M4M3Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - dehydration

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 65 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD30 - Lethal Dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Kidney

DOSE/DURATION :: 2 mmol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 40,1893,1990

精胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
C: Corrosive;Xi: Irritant;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36-S45-S36/37/39

[ 危险品运输编码 ]:
UN 3259 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
EJ7230000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2929909090

精胺合成路线

精胺上下游产品

精胺上游产品

精胺下游产品

精胺海关

[ 海关编码 ]: 2921290000

[ 中文概述 ]:
2921290000. 其他无环多胺及其衍生物及它们的盐. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

精胺文献

H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.

J. Endocrinol. 223(3) , 241-53, (2014)

The histamine H4 receptor (HRH4), discovered only 13 years ago, is considered a promising drug target for allergy, inflammation, autoimmune disorders and cancer, as reflected by a steadily growing num...

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy.

Breast Cancer Res. 17 , 19, (2015)

Targeted therapies for aggressive breast cancers like triple negative breast cancer (TNBC) are needed. The use of small interfering RNAs (siRNAs) to disable expression of survival genes provides a too...

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

Toxicol. Appl. Pharmacol. 282(1) , 77-89, (2015)

The intracellular level of bilirubin (BR), an endogenous antioxidant that is cytotoxic at high concentrations, is tightly controlled within the optimal therapeutic range. We have recently described a ...

更多文献

精胺