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5-Butyl-1-cyclohexylbarbituric acid

5-Butyl-1-cyclohexylbarbituric acid用途

Bucolome 是一种 CYP2C9 抑制剂,为有效的排尿酸药和抗炎药。

5-Butyl-1-cyclohexylbarbituric acid名称

[ CAS 号 ]:
841-73-6

[ 中文名 ]:
丁基环已基巴比妥

[ 英文名 ]:
Bucolome

[中文别名 ]:

丁环已嘧三酮

[英文别名 ]:

5-butyl-1-cyclohexyl-pyrimidine-2,4,6-trione
5-butyl-1-cyclohexyl-1,3-diazinane-2,4,6-trione
Paramidin
bucolome
Bucolom
EINECS 212-666-1
Paramidine
1-Cyclohexyl-5-butylbarbitursaeure
5-Butyl-1-cyclohexylbarbituric acid

5-Butyl-1-cyclohexylbarbituric acid生物活性

[ 描述 ]:

Bucolome 是一种 CYP2C9 抑制剂,为有效的排尿酸药和抗炎药。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 细胞色素P450

研究领域 >> 炎症/免疫

[体外研究]

布可洛姆是一种有效的(S)-华法林7-羟基化的混合型抑制剂,Ki分别为8.2μM和20.2μM[1]。

[参考文献]

[1]. Takahashi H, et al. Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance. Drug Metab Dispos. 1999 Oct;27(10):1179-86.

5-Butyl-1-cyclohexylbarbituric acid物理化学性质

[ 密度 ]:
1.139 g/cm3

[ 沸点 ]:
bp0.8 185-187°

[ 熔点 ]:
84°

[ 分子式 ]:
C₁₄H₂₂N₂O₃

[ 分子量 ]:
266.33600

[ 精确质量 ]:
266.16300

[ PSA ]:
66.48000

[ LogP ]:
2.47060

[ 折射率 ]:
1.511

[ 储存条件 ]:
库房低温干燥通风

5-Butyl-1-cyclohexylbarbituric acid毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CQ1497900

CHEMICAL NAME :: Barbituric acid, 5-butyl-1-cyclohexyl-

CAS REGISTRY NUMBER :: 841-73-6

BEILSTEIN REFERENCE NO. :: 0755320

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H22-N2-O3

MOLECULAR WEIGHT :: 266.38

WISWESSER LINE NOTATION :: T6VMVNV FHJ F4 D- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1115 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 455 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1550 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,43,1967 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2800 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,381,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 25200 mg/kg

SEX/DURATION :: male 36 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 63,105,1967

5-Butyl-1-cyclohexylbarbituric acid安全信息

[ 海关编码 ]:
2933540000

5-Butyl-1-cyclohexylbarbituric acid海关

[ 海关编码 ]: 2933540000

[ 中文概述 ]:
2933540000 其他丙二酰脲（巴比土酸）的衍生物以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933540000 other derivatives of malonylurea (barbituric acid); salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%