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依那普利那二水

依那普利那二水用途

Enalaprilat是血管紧张素转化酶(ACE)抑制剂,IC50为1.94 nM。

依那普利那二水名称

[ CAS 号 ]:
84680-54-6

[ 中文名 ]:
依那普利那二水

[ 英文名 ]:
Enalaprilat Dihydrate

[中文别名 ]:

[英文别名 ]:

MFCD00941393
ENALAPRILAT DIHYDRATE
EINECS 278-459-3

依那普利那二水生物活性

[ 描述 ]:

Enalaprilat是血管紧张素转化酶(ACE)抑制剂,IC50为1.94 nM。

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

信号通路 >> 自噬 >> 自噬

研究领域 >> 心血管疾病

[参考文献]

[1]. Ceconi, C., et al., Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol, 2007. 577(1-3): p. 1-6.

[2]. van Eickels, M., H. Vetter, and C. Grohe, Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol, 2000. 131(8): p. 1592-6.

[3]. Schumacher, J., et al., Effects of candesartan and enalaprilat on the organ-specific microvascular permeability during haemorrhagic shock in rats. Br J Anaesth, 2006. 96(4): p. 437-43.

[相关活性小分子]

依那普利那二水物理化学性质

[ 沸点 ]:
563.5ºC at 760 mmHg

[ 熔点 ]:
211-215°C

[ 分子式 ]:
C₁₈H₂₈N₂O₇

[ 分子量 ]:
384.424

[ 闪点 ]:
294.6ºC

[ 精确质量 ]:
384.189636

[ PSA ]:
125.40000

[ LogP ]:
1.32630

[ 外观性状 ]:
白色-极淡的黄色晶体-粉末

[ 折射率 ]:
1.579

[ 储存条件 ]:
-20°C Freezer

依那普利那二水MSDS

详细MSDS(安全技术说明书)

依那普利那二水安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S22-S26-S36/37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
TW3590600

依那普利那二水文献

Evaluation of a rapid method for the therapeutic drug monitoring of aliskiren, enalapril and its active metabolite in plasma and urine by UHPLC-MS/MS.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 980 , 79-87, (2015)

Given the increasing popularity of aliskiren, particularly in combination with angiotensin converting enzyme inhibitor (e.g. enalapril), it is important to determine whether its use in combination wit...

Role of multidrug resistance-associated protein 4 in the basolateral efflux of hepatically derived enalaprilat.

Drug Metab. Dispos. 42(9) , 1567-74, (2014)

Hepatic uptake and efflux transporters govern the systemic and hepatic exposure of many drugs and metabolites. Enalapril is a pharmacologically inactive prodrug of enalaprilat. Following oral administ...

Enalaprilat.

Dimens. Crit. Care Nurs. 19(2) , 22, (2000)

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