青霉素V
青霉素V用途
青霉素V名称
[ CAS 号 ]:
87-08-1
[ 中文名 ]:
青霉素V
[ 英文名 ]:
Penicillin-V
[中文别名 ]:
[英文别名 ]:
- penicillin-V
- Oracillin
- Pen-vee-oral
- Fenospen
- Penicillin phenoxymethyl
- PenicillinV
- Phenocillin
- Beromycin
- Phenopenicillin
- Acipen-V
青霉素V生物活性
[ 描述 ]:
[ 相关类别 ]:
[体外研究]
[体内研究]
[参考文献]
青霉素V物理化学性质
[ 密度 ]:
1.5±0.1 g/cm3
[ 沸点 ]:
681.4±55.0 °C at 760 mmHg
[ 熔点 ]:
120 - 128ºC
[ 分子式 ]:
C16H18N2O5S
[ 分子量 ]:
350.389
[ 闪点 ]:
365.9±31.5 °C
[ 精确质量 ]:
350.093628
[ PSA ]:
121.24000
[ LogP ]:
1.88
[ 外观性状 ]:
白色至灰白色结晶粉末
[ 蒸汽压 ]:
0.0±2.2 mmHg at 25°C
[ 折射率 ]:
1.651
[ 储存条件 ]:
−20°C
[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.
[ 水溶解性 ]:
Very slightly soluble in water, soluble in ethanol (96 per cent).
青霉素V毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RY4025000
- CHEMICAL NAME :
- Penicillanic acid, 6-phenoxyacetamido-
- CAS REGISTRY NUMBER :
- 87-08-1
- BEILSTEIN REFERENCE NO. :
- 0096259
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C16-H18-N2-O5-S
- MOLECULAR WEIGHT :
- 350.42
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ CMV1OR& F1 F1 GVQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 10 mg/kg/2D
- TOXIC EFFECTS :
- Liver - liver function tests impaired Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2220 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1775 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1600 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6578 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1351 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1775 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 822 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 1096 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Ascites tumor
- DOSE/DURATION :
- 200 ug/L
- REFERENCE :
- NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 22,105,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83957 No. of Facilities: 61 (estimated) No. of Industries: 2 No. of Occupations: 6 No. of Employees: 2874 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83957 No. of Facilities: 114 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1964 (estimated) No. of Female Employees: 959 (estimated)
青霉素V安全信息
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
R42/43
[ 安全声明 (欧洲) ]:
22-36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ RTECS号 ]:
RY4025000
[ 海关编码 ]:
3003101300
青霉素V合成路线
青霉素V上下游产品
青霉素V上游产品
青霉素V下游产品
青霉素V海关
[ 海关编码 ]: 3003101300
青霉素V文献
Forensic Sci. Int. 243 , 35-43, (2014)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction...
Molecularly imprinted polymer nanocarriers for sustained release of erythromycin.Pharm. Res. 32(2) , 375-88, (2015)
To develop and evaluate molecularly imprinted nanocarriers for sustained release of erythromycin in physiological buffer media.Erythromycin-imprinted poly(methacrylic acid-co-trimethylolpropane trimet...
Follow-up study of implants with turned or oxidized surfaces placed after sinus augmentation.Int. J. Oral Maxillofac. Implants 29(6) , 1380-7, (2014)
To compare long-term survival and clinical outcomes of endosseous implants with different surface characteristics in patients with sinus elevation procedures, autologous bone grafting, and delayed imp...
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标题:青霉素V_用途_密度_熔点_青霉素VCAS号【87-08-1】_化源网 地址:https://www.chemsrc.com/amp/cas/87-08-1_1103428.html