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吲哚-3-乙酸

吲哚-3-乙酸用途

Indole-3-acetic acid (3-Indoleacetic acid; IAA)是最常见的天然植物生长激素。它可以添加到细胞培养基中用来诱导植物细胞伸长和分裂。

吲哚-3-乙酸名称

[ CAS 号 ]:
87-51-4

[ 中文名 ]:
杂茁长素

[ 英文名 ]:
3-Indoleacetic acid

[中文别名 ]:

[英文别名 ]:

1H-Indol-3-ylacetic acid
INDOLYL 3-ACETIC ACID
1H-Indole-3-acetic acid
b-Iaa
3-(Carboxymethyl)Indole
2-(1H-INDOL-3-YL)ACETIC ACID
2-(3-Indolyl)acetic acid
INDOLE3ACETICACID
3-Indolyl-acetic acid
3-Indolylacetic Acid

吲哚-3-乙酸生物活性

[ 描述 ]:

Indole-3-acetic acid (3-Indoleacetic acid; IAA)是最常见的天然植物生长激素。它可以添加到细胞培养基中用来诱导植物细胞伸长和分裂。

[ 相关类别 ]:

研究领域 >> 其他

生化试剂

天然产物 >> 糖和糖苷

[ 靶点 ]

Human Endogenous Metabolite

[相关活性小分子]

吲哚-3-乙酸物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
415.0±20.0 °C at 760 mmHg

[ 熔点 ]:
165-169 °C(lit.)

[ 分子式 ]:
C₁₀H₉NO₂

[ 分子量 ]:
175.184

[ 闪点 ]:
204.8±21.8 °C

[ 精确质量 ]:
175.063324

[ PSA ]:
53.09000

[ LogP ]:
1.43

[ 外观性状 ]:
白色至黄褐色的晶体

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.694

[ 储存条件 ]:
−20°C

吲哚-3-乙酸MSDS

吲哚-3-乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL3150000

CHEMICAL NAME :: 1H-Indole-3-acetic acid

CAS REGISTRY NUMBER :: 87-51-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C10-H9-N-O2

MOLECULAR WEIGHT :: 175.20

WISWESSER LINE NOTATION :: T56 BMJ D1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2000 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumor types after systemic administration not seen spontaneously

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 450 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4500 mg/kg

SEX/DURATION :: female 7-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 250 umol/L

REFERENCE :: PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 11,3135,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83421 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 27 (estimated)

吲哚-3-乙酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
NL3150000

[ 包装等级 ]:
II

[ 海关编码 ]:
2933990090

吲哚-3-乙酸合成路线

吲哚-3-乙酸上下游产品

吲哚-3-乙酸上游产品

吲哚-3-乙酸下游产品

吲哚-3-乙酸制备

1.由吲哚与羟基乙酸反应而得。在3L不锈钢高压釜中，加入270g（4.1mol）85%在氢氧化钾，351g（3mol）吲哚，然后慢慢地加入360g（3.3mol）70%的羟基乙酸水溶液。密闭加热至250℃，搅拌18h。冷却至50℃以下，加入500ml水，再在100℃搅拌30min以溶解吲哚3-乙酸钾。冷却至25℃，将高压釜物料倒入水中，加水至总体积为3L。用500ml乙醚萃取，分取水层，在20-30℃加盐酸酸化，析出吲哚-3-乙酸沉淀。过滤，冷水洗涤，避光干燥，得产品455-490g。

2.由吲哚与羟基乙酸反应，经过滤、冷水洗涤、干燥即可。

吲哚-3-乙酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

吲哚-3-乙酸文献

A new enabling proteomics methodology to investigate membrane associated proteins from parasitic nematodes: case study using ivermectin resistant and ivermectin susceptible isolates of Caenorhabditis elegans and Haemonchus contortus.

Vet. Parasitol. 207(3-4) , 266-75, (2015)

The mechanisms involved in anthelmintic resistance (AR) are complex but a greater understanding of AR management is essential for effective and sustainable control of parasitic helminth worms in lives...

FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis.

Nat. Commun. 5 , 5473, (2014)

Global warming is predicted to profoundly affect plant distribution and crop yield in the near future. Higher ambient temperature can influence diverse aspects of plant growth and development. In Arab...

Potential predictive plasma biomarkers for cervical cancer by 2D-DIGE proteomics and Ingenuity Pathway Analysis.

Tumour Biol. 36(3) , 1711-20, (2015)

The current methods available for screening and detecting cervical squamous cell carcinoma (CSCC) have insufficient sensitivity and specificity. As a result, many patients suffered from erroneous and ...

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