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2,5-二叔丁基对苯二酚

2,5-二叔丁基对苯二酚用途

2,5-Di-tert-butylhydroquinone (DTBHQ) 是一种间接的食品添加剂,可调节 5-LO 以及 COX-2 活性,IC50 分别为 1.8 和 14.1 μM。

2,5-二叔丁基对苯二酚名称

[ CAS 号 ]:
88-58-4

[ 中文名 ]:
2,5-二叔丁基对苯二酚

[ 英文名 ]:
2,5-Di-tert-butylhydroquinone

[中文别名 ]:

[英文别名 ]:

2,5-Bis(2-methyl-2-propanyl)-1,4-benzenediol
MFCD00008825
2,5-TBHQ
EINECS 201-841-8
1,4-Benzenediol, 2,5-bis(1,1-dimethylethyl)-
2,5-Di-tert-Butyl-1,4-hydroquinone (DBHQ)
2,5-di-tert-butylhydroquinone
2,5-Di-tert-butylbenzene-1,4-diol
2,5-DITERT-BUTYLBENZENE-1,4-DIOL
2,5-Di-tert-butyl-1,4-hydroquinone

2,5-二叔丁基对苯二酚生物活性

[ 描述 ]:

2,5-Di-tert-butylhydroquinone (DTBHQ) 是一种间接的食品添加剂,可调节 5-LO 以及 COX-2 活性,IC50 分别为 1.8 和 14.1 μM。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

信号通路 >> 代谢酶/蛋白酶 >> 5脂氧合酶

信号通路 >> 免疫及炎症 >> COX

[ 靶点 ]

5-LO:1.8 μM (IC50)

COX-2:14.1 μM (IC50)

[体外研究]

DTBHQ在体外影响花生四烯酸(AA)代谢的生物学相关浓度[1]。

[参考文献]

[1]. Zsofia Kutil, et al. The influence of the quinone antioxidants tert-butylhydroquinone and 2,5-di-tert-butylhydroquinone on the arachidonic acid metabolism in vitro. Food and Agricultural Immunology. Volume 26, 2015-Issue 4.

2,5-二叔丁基对苯二酚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
334.4±37.0 °C at 760 mmHg

[ 熔点 ]:
216-218 °C(lit.)

[ 分子式 ]:
C₁₄H₂₂O₂

[ 分子量 ]:
222.323

[ 闪点 ]:
151.5±21.1 °C

[ 精确质量 ]:
222.161987

[ PSA ]:
40.46000

[ LogP ]:
4.02

[ 外观性状 ]:
白色或淡黄色晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.520

[ 储存条件 ]:
Store at RT

[ 稳定性 ]:
Stable. Incompatible with oxidizing agents.

[ 水溶解性 ]:
水溶性：不溶；水溶解度：0.02 g/l 20 °C；易溶于：丙酮,甲醇,乙醇；微溶：氯仿,甲苯

2,5-二叔丁基对苯二酚MSDS

2,5-二叔丁基对苯二酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX5160000

CHEMICAL NAME :: Hydroquinone, 2,5-di-tert-butyl-

CAS REGISTRY NUMBER :: 88-58-4

BEILSTEIN REFERENCE NO. :: 2049542

LAST UPDATED :: 199707

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C14-H22-O2

MOLECULAR WEIGHT :: 222.36

WISWESSER LINE NOTATION :: L6V DVJ BX1&1&1 EX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6426 mg/kg/3W-C

TOXIC EFFECTS :: Blood - change in clotting factors Related to Chronic Data - death

REFERENCE :: JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 109,453,1979 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 134 gm/kg/24W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - tumors

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 12,1341,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7949 No. of Facilities: 155 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 14136 (estimated) No. of Female Employees: 6832 (estimated)

2,5-二叔丁基对苯二酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
MX5160000

[ 海关编码 ]:
29072900

2,5-二叔丁基对苯二酚合成路线

2,5-二叔丁基对苯二酚上下游产品

2,5-二叔丁基对苯二酚上游产品

2,5-二叔丁基对苯二酚下游产品

2,5-二叔丁基对苯二酚制备

1.异丁烯的制备异丁醇经气化后，连续定量地通过触媒活性氧化铝，在(380±10)℃下进行脱水反应。生成的异丁烯气体。经冷却、分水、干燥，供烷基化使用。

防老剂Alba的制备在反应釜内加入对苯二酚和催化剂硫酸，搅拌下加热至65℃时通入异丁烯，进行烷基化反应。反应生成防老剂Alba,经60℃热水洗涤，再用碳酸钠中和，最后再用70～80℃的水洗至中性、冷却至10～15℃结晶，离心脱水后溶于热乙醇中进行重结晶，即得成品。

2.由对苯二酚与异丁烯反应制得。反应式如下：

2,5-二叔丁基对苯二酚海关

[ 海关编码 ]: 2907299090

[ 中文概述 ]:
2907299090 其他多元酚，酚醇。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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