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N-苯基哌嗪

N-苯基哌嗪用途

【用途一】
左羟丙哌嗪的中间体

N-苯基哌嗪名称

[ CAS 号 ]:
92-54-6

[ 中文名 ]:
N-苯基哌嗪

[ 英文名 ]:
1-Phenylpiperazine

[中文别名 ]:

1-苯基哌嗪

[英文别名 ]:

phenyl piperazine
MFCD00005957
1-phenyl-piperazine
4-Phenylpiperazine
Phenylpiperazine
1-Fenylpiperazin
1-PHENYLPIPERAZINE
1-fenylpiperazine
N-PHENYLPIPERAZINE
1-PHENYLPIPERAINE

N-苯基哌嗪物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
287.2±15.0 °C at 760 mmHg

[ 熔点 ]:
18.8 °C

[ 分子式 ]:
C₁₀H₁₄N₂

[ 分子量 ]:
162.232

[ 闪点 ]:
138.3±11.4 °C

[ 精确质量 ]:
162.115692

[ PSA ]:
15.27000

[ LogP ]:
1.11

[ 外观性状 ]:
透明至淡黄色液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.544

[ 储存条件 ]:
Store in dark!

[ 水溶解性 ]:
Insoluble

N-苯基哌嗪MSDS

N-苯基哌嗪毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM2625000

CHEMICAL NAME :: Piperazine, 1-phenyl-

CAS REGISTRY NUMBER :: 92-54-6

BEILSTEIN REFERENCE NO. :: 0132157

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C10-H14-N2

MOLECULAR WEIGHT :: 162.26

WISWESSER LINE NOTATION :: T6M DNTJ DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 140 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: DNA damage

MUTATION DATA

TYPE OF TEST :: Micronucleus test

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 900 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 282,99,1992

N-苯基哌嗪安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311-H314

[ 警示性声明 ]:
Missing Phrase - N15.00950417-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic;

[ 风险声明 (欧洲) ]:
R22;R24;R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S28A

[ 危险品运输编码 ]:
UN 2922 8/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
TM2625000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29335995

N-苯基哌嗪合成路线

N-苯基哌嗪上下游产品

N-苯基哌嗪上游产品

N-苯基哌嗪下游产品

N-苯基哌嗪制备

由2-(2-氨基乙基氨基)-2-苯基乙醇 [H2NCH2CH2NHCH(C6H5)CH2OH]在高压釜中于220℃脱水环化制取。

N-苯基哌嗪海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

N-苯基哌嗪文献

Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

J. Med. Chem. 53(6) , 2510-20, (2010)

Modification of the partial dopamine type 2 receptor (D(2)) agonist 3-(1-benzylpiperidin-4-yl)phenol (9a) generated a series of novel functional D(2) antagonists with fast-off kinetic properties. A re...

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

J. Med. Chem. 52(15) , 4923-35, (2009)

Assembling phenylpiperazines with 7a-azaindole via different spacer elements, we developed subtype selective dopamine receptor ligands of types 1a,c, 2a, and 3a preferentially interacting with D4, D2,...

Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.

J. Chromatogr. A. 1217(40) , 6274-80, (2010)

A simple and sensitive procedure, using p-tolylpiperazine (pTP) as internal standard (IS), has been developed and validated for the qualitative and quantitative analysis of 1-(3-trifuoromethylphenyl)p...

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