DGAT-1抑制剂2

DGAT-1 inhibitor 2是有效的DGAT-1抑制剂,具有减肥功效。

信号通路 >> 代谢酶/蛋白酶 >> 酰基转移酶

研究领域 >> 代谢疾病

[1]. Matsuda D, Tomoda H. DGAT inhibitors for obesity. Curr Opin Investig Drugs. 2007 Oct;8(10):836-41.

[2]. Birch, Alan M.; Birtles, Susan; Buckett, Linda K. et al. Discovery of a Potent, Selective, and Orally Efficacious Pyrimidinooxazinyl Bicyclooctaneacetic Acid Diacylglycerol Acyltransferase-1 Inhibitor. Journal of Medicinal Chemistry (2009), 52(6), 1558-15

[3]. King AJ, Judd AS, Souers AJ. Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents. Expert Opin Ther Pat. 2010 Jan;20(1):19-29.

[4]. Cao J, Zhou Y, Peng H et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J Biol Chem. 2011 Dec 2;286(48):41838-51.

阿伐麦布 | Pradigastat | 反式-4-[4-(4-氨基-7,7-二甲基-7H-嘧啶并[4,5-B][1,4]噁唑-6-基)苯基]-环己基乙酰胺 | DGAT-1 抑制剂 | 黄腐酚 | 反式-4-[4-(4-氨基-7,8-二氢-5-氧代嘧啶并[5,4-f][1,4]氧氮杂卓-6(5H)-基)苯基]环己烷乙酸 | AZD7687 | MGAT2-IN-1 | DGAT1-IN-1 | K-604二盐酸盐 | PF-06471553 | YM17E | ABT-046 | RP 70676 | 糠酸; 2-糠酸; 2-呋喃甲酸