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甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸

甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸用途

Gly-Arg-Gly-Asp-Ser 是一种五肽,构成了糖蛋白,骨桥蛋白与细胞的结合域。

甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸名称

[ CAS 号 ]:
96426-21-0

[ 中文名 ]:
甘氨酰精氨酰甘氨酰天门冬氨酰丝氨酸

[ 英文名 ]:
H-Gly-Arg-Gly-Asp-Ser-OH

[英文别名 ]:

Gly-Arg-Gly-Asp-Ser-OH
GRGDS 1/2ACOH 2H2O
H-GLY-ARG-GLY-ASP-SER-OH
GRGDS
GRGDS,FIBRONECTIN ATTACHMENT PEPTIDE
glycyl-arginyl-glycyl-aspartyl-serine
MFCD00076459
L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl

甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸生物活性

[ 描述 ]:

Gly-Arg-Gly-Asp-Ser 是一种五肽,构成了糖蛋白,骨桥蛋白与细胞的结合域。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

多肽产品

[体外研究]

Gly-Arg-Gly-Asp-Ser与整合素受体αvβ3结合,IC50为5μM[1]。 GRGDS固定化的TiO2纳米管可增强成骨细胞样细胞(MG-63)的粘附,并显着增加细胞的扩散和增殖[2]。

[参考文献]

[1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997.

[2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.

[相关活性小分子]

甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸物理化学性质

[ 密度 ]:
1.66 g/cm3

[ 分子式 ]:
C₁₇H₃₀N₈O₉

[ 分子量 ]:
490.46800

[ 精确质量 ]:
490.21400

[ PSA ]:
299.15000

[ 外观性状 ]:
固体

[ 折射率 ]:
1.664

[ 储存条件 ]:
-20℃，密封，干燥

甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸合成路线

详细合成路线

甘氨酸-精氨酸-甘氨酸-天冬氨酸,丝氨酸文献

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