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促进剂DOTG

促进剂DOTG用途

Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) 是一种 sigma 受体 (σ1/σ2 receptor) 激动剂。

促进剂DOTG名称

[ CAS 号 ]:
97-39-2

[ 中文名 ]:
1,3-二-邻-甲苯基胍

[ 英文名 ]:
Ditolylguanidine

[中文别名 ]:

[英文别名 ]:

MFCD00008513
1,3-Bis(o-tolyl)guanidine
Guanidine, N,N''-bis(2-methylphenyl)-
N,N'-Di-o-tolylguanidine
EINECS 202-577-6
N,N'-Bis(2-methylphenyl)guanidine
Di-o-tolylguanidine
Guanidine, 1,3-di-o-tolyl-
1R BMYUM&MR B1
1,2-Bis(2-methylphenyl)guanidine

促进剂DOTG生物活性

[ 描述 ]:

Ditolylguanidine (1,3-Di-o-tolylguanidine; DTG) 是一种 sigma 受体 (σ1/σ2 receptor) 激动剂。

[ 相关类别 ]:

研究领域 >> 神经疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Sigma Receptor

[ 靶点 ]

Sigma receptor[1]

[参考文献]

[1]. Skuza G, et al. Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats. Pol J Pharmacol. 2003 Nov-Dec;55(6):1149-52.

促进剂DOTG物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
396.1±45.0 °C at 760 mmHg

[ 熔点 ]:
176-178 °C(lit.)

[ 分子式 ]:
C₁₅H₁₇N₃

[ 分子量 ]:
239.32

[ 闪点 ]:
193.3±28.7 °C

[ 精确质量 ]:
239.142242

[ PSA ]:
47.91000

[ LogP ]:
3.77

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.585

[ 储存条件 ]:
Store at RT

促进剂DOTGMSDS

促进剂DOTG毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MF1400000

CHEMICAL NAME :: Guanidine, 1,3-di-o-tolyl-

CAS REGISTRY NUMBER :: 97-39-2

BEILSTEIN REFERENCE NO. :: 2653884

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C15-H17-N3

MOLECULAR WEIGHT :: 239.35

WISWESSER LINE NOTATION :: 1R BMYUM&MR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,87,1931 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81800 No. of Facilities: 157 (estimated) No. of Industries: 5 No. of Occupations: 23 No. of Employees: 3729 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81800 No. of Facilities: 492 (estimated) No. of Industries: 7 No. of Occupations: 18 No. of Employees: 22254 (estimated) No. of Female Employees: 4255 (estimated)

促进剂DOTG安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 2811

[ WGK德国 ]:
3

[ RTECS号 ]:
MF1400000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2925290090

促进剂DOTG合成路线

促进剂DOTG上下游产品

促进剂DOTG上游产品

促进剂DOTG下游产品

促进剂DOTG制备

可由氯化氰与邻甲苯胺反应后水解而得，或由邻甲苯胺与二硫化碳作用成二邻甲苯基硫脲，再在氨水中用氧化铅脱硫而得。

促进剂DOTG海关

[ 海关编码 ]: 2925290090

[ 中文概述 ]:
2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

促进剂DOTG文献

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