糠醇

糠醇用途

【用途一】
用作合成各种呋喃型树脂的原料、防腐涂料，亦是良好的溶剂
【用途二】
是树脂、清漆、颜料的良好溶剂和火箭燃料，还可用于合成纤维、橡胶、农药及铸造行业
【用途三】
GB 2761--1997规定为允许使用的食品用香料。主要用于配制焦香型香精。
FDA，§175．105：规定为非直接食品添加剂(粘结剂)。
【用途四】
糠醇用于有机合成，经水解制得乙酰丙酸（果酸）是营养药物果糖酸钙的中间体。由糠醇可制得各种性能的呋喃型树脂（如糠醇树脂，呋喃Ⅰ或呋喃Ⅱ型树脂），糠醇-脲醛树脂及酚醛树脂等；由糠醇制得的增塑剂的耐寒性优于丁，辛醇酯类，又是呋喃树脂，清漆，颜料的良好溶剂和火箭燃料。此外还用于合成纤维，橡胶，农药和铸造工业等。该品易燃，有毒。小鼠口服LD50为275mg/kg。
【用途五】
溶剂。有机合成(制造蒽、树脂等)。防腐剂。香料。

糠醇名称

[ CAS 号 ]:
98-00-0

[ 中文名 ]:
糠醇

[ 英文名 ]:
Furfuryl alcohol

[中文别名 ]:

[英文别名 ]:

T5OJ B1Q
2-Furanylmethanol
HPFA
2-(Hydroxymethyl)furan
furfralcohol
2-Furylmethanol
furan-2-methanol
FEMA 2491
5-HYDROXYMETHYL FURAN
Methanol, (2-furyl)-

糠醇物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
170.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-29 °C

[ 分子式 ]:
C₅H₆O₂

[ 分子量 ]:
98.100

[ 闪点 ]:
65.0±0.0 °C

[ 精确质量 ]:
98.036781

[ PSA ]:
33.37000

[ LogP ]:
0.20

[ 外观性状 ]:
透明黄色液体

[ 蒸汽密度 ]:
3.4 (vs air)

[ 蒸汽压 ]:
1.0±0.3 mmHg at 25°C

[ 折射率 ]:
1.493

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂、酸分开存放

[ 水溶解性 ]:
MISCIBLE

[ 凝固点 ]:
-29℃

糠醇MSDS

详细MSDS(安全技术说明书)

糠醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU9100000

CHEMICAL NAME :: Furfuryl alcohol

CAS REGISTRY NUMBER :: 98-00-0

BEILSTEIN REFERENCE NO. :: 0106291

LAST UPDATED :: 199712

DATA ITEMS CITED :: 51

MOLECULAR FORMULA :: C5-H6-O2

MOLECULAR WEIGHT :: 98.11

WISWESSER LINE NOTATION :: T5OJ B1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 177 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 233 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3825 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 85 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 597 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 338 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 632 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/m3/2W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 ppm/6H/16W-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 22 mg/m3/17W-I

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

REFERENCE :: CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 13,89,1981 *** REVIEWS *** ACGIH TLV-STEL 60 mg/m3 (15 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 40 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (20 mg/m3) (skin) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,19,1973 OSHA PEL (Gen Indu):8H TWA 50 ppm (200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 50 ppm (200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 50 ppm (200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 50 ppm (200 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (40 mg/m3);STEL 15 ppm (60 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 10 ppm (40 mg/m3);STEL 15 ppm (60 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 10 ppm (40 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (200 mg/m3) JAN 1993 OEL-HUNGARY:STEL 8 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (20 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (20 mg/m3);STEL 50 ppm;Skin JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (200 mg/m3) JAN 1993 OEL-RUSSIA:TWA 5 ppm;STEL 0.5 mg/m3;Skin JAN 1993 OEL-SWEDEN:TWA 5 ppm (20 mg/m3);STEL 10 ppm (40 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (40 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 50 ppm (200 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);STEL 15 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO FURFURYL ALCOHOL-air:TWA 10 ppm (Sk);STEL 15 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 34370 No. of Facilities: 2939 (estimated) No. of Industries: 29 No. of Occupations: 38 No. of Employees: 11577 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 34370 No. of Facilities: 2827 (estimated) No. of Industries: 46 No. of Occupations: 63 No. of Employees: 77710 (estimated) No. of Female Employees: 14624 (estimated)

糠醇安全信息

[ 符号 ]:

GHS06, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301 + H311-H315-H319-H330-H335-H351-H373

[ 警示性声明 ]:
P260-P280-P284-P301 + P310 + P330-P304 + P340 + P310-P403 + P233

[ 靶器官 ]:
Nose

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
T:Toxic

[ 风险声明 (欧洲) ]:
R21/22;R23;R36/37;R40;R48/20

[ 安全声明 (欧洲) ]:
S23-S36/37/39

[ 危险品运输编码 ]:
UN 2874 6.1/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
LU9100000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2932130000

糠醇合成路线

详细合成路线

糠醇上下游产品

糠醇上游产品

糠醇下游产品

糠醇制备

1.精制方法：用无水硫酸钠或无水碳酸钾干燥后分馏。分馏最好在氮气流下进行。也可以先进行减压蒸馏，除去焦油状物质，再和亚硫酸氢钠水溶液一起摇动，无水硫酸钠干燥后在碳酸钠存在下减压分馏。

2. 糠醇的工业制法是由糠醛加氢制得：

加氢分为液相加氢和气相加氢两种。液相加氢法：糠醛与氢气以1∶ 42（摩尔比）的比例在Cu-Cr —Ca系催化剂存在下，于190～210℃，5-8MPa下（或10MPa以上，170℃，采用Cu—Cr催化剂）进行反应，反应结束后，沉降，除去固体催化剂，所得液体为糠醇粗品。气相加氢法：在列管式反应器中，糠醛与氢气以1∶ 42（摩尔比）在Ni-Cu或Cr-Cu系催化剂存在下，于80～170℃，0.1～0.39MPa下反应制得。所得粗糠醇于80～87kPa下减压精馏以除去焦油状物质，然后用亚硫酸氢钠洗涤，干燥脱水后，再加入碳酸钠进行减压蒸馏，即得纯品呋喃甲醇。

3.歧化法　以糠醛为原料，使糠醛在烧碱存在下发生歧化反应，该法的优点是设备简单，不需要还原剂，缺点是原料利用率低。

4.烟草：BU，56；OR，18；FC，9；FC，BU，OR，18；FC，18；FC，40。

糠醇海关

[ 海关编码 ]: 2932130000

[ 中文概述 ]:
HS: 2932130000. 糠醇及四氢糠醇. 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最低关税:6.0%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2932130000. (tetrahydrofuran-2-yl)methanol. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tarrif:6.0%. general tariff:20.0%

糠醇文献

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Food Chem. 166 , 301-8, (2014)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indi...

The effect of knockout of sulfotransferases 1a1 and 1d1 and of transgenic human sulfotransferases 1A1/1A2 on the formation of DNA adducts from furfuryl alcohol in mouse models.

Carcinogenesis 35(10) , 2339-45, (2014)

Furfuryl alcohol is a rodent carcinogen present in numerous foodstuffs. Sulfotransferases (SULTs) convert furfuryl alcohol into the DNA reactive and mutagenic 2-sulfoxymethylfuran. Sensitive technique...

Folate-polyethyleneimine functionalized mesoporous carbon nanoparticles for enhancing oral bioavailability of paclitaxel.

Int. J. Pharm. 484(1-2) , 207-17, (2015)

Polymer-functionalized carbon nanoparticles hold great promise for their use in enhancing the oral absorption of drugs with poor oral bioavailability. And since the abundant expression of folate recep...

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糠醇