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5-羟甲基糠醛

5-羟甲基糠醛用途

5-(Hydroxymethyl)furan-2-carbaldehyde,来自木质生物质,能抑制酵母的生长和发酵。

5-羟甲基糠醛名称

[ CAS 号 ]:
67-47-0

[ 中文名 ]:
5-羟甲基糠醛

[ 英文名 ]:
5-hydroxymethylfurfural

[中文别名 ]:

[英文别名 ]:

HMF
EINECS 200-654-9
5-(Hydroxymethyl)furan-2-carboxaldehyde
T5OJ BVH E1Q
5-(Hydroxymethyl)-2-furancarboxaldehyde
5-(Hydroxymethyl)furan-2-carbaldehyde
Aes-103
5-(Hydroxymethyl)furfural
5-Hydroxymethylfurfural
2-Furancarboxaldehyde, 5-(hydroxymethyl)-

5-羟甲基糠醛生物活性

[ 描述 ]:

5-(Hydroxymethyl)furan-2-carbaldehyde,来自木质生物质,能抑制酵母的生长和发酵。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 真菌

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Yeast[1].

[体外研究]

发现糠醛和HMF导致体细胞翻译活性的减弱和细胞质mRNP颗粒在酿酒酵母中的组装。值得注意的是,糠醛和HMF的组合诱导了翻译起始和SG形成的显着抑制。糠醛和HMF可以诱导细胞质mRNP颗粒的形成,HMF也导致多核糖体部分的逐渐减少和80S单体部分的伴随增加[1]。

[参考文献]

[1]. Iwaki A, et al. Biomass conversion inhibitors furfural and 5-hydroxymethylfurfural induce formation of messenger RNP granules and attenuate translation activity in Saccharomyces cerevisiae. Appl Environ Microbiol. 2013 Mar;79(5):1661-7.

[相关活性小分子]

5-羟甲基糠醛物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
291.5±30.0 °C at 760 mmHg

[ 熔点 ]:
28-34 °C(lit.)

[ 分子式 ]:
C₆H₆O₃

[ 分子量 ]:
126.110

[ 闪点 ]:
79.4±0.0 °C

[ 精确质量 ]:
126.031693

[ PSA ]:
50.44000

[ LogP ]:
-0.45

[ 外观性状 ]:
米色有色的结晶固体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.563

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Light Sensitive, Very Hygroscopic

[ 水溶解性 ]:
水溶性：完全溶解；易溶于：二甲基甲酰胺,乙醇,丙酮,甲醇；可溶于：氯仿,苯,乙醚

5-羟甲基糠醛MSDS

5-羟甲基糠醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LT7031100

CHEMICAL NAME :: 2-Furaldehyde, 5-(hydroxymethyl)-

CAS REGISTRY NUMBER :: 67-47-0

BEILSTEIN REFERENCE NO. :: 0110889

LAST UPDATED :: 199712

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C6-H6-O3

MOLECULAR WEIGHT :: 126.12

WISWESSER LINE NOTATION :: T5OJ BVH E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 227,117,1989

5-羟甲基糠醛安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
LT7031100

[ 包装等级 ]:
III

[ 海关编码 ]:
2932190090

5-羟甲基糠醛合成路线

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5-羟甲基糠醛制备

1. 烟草：FC，9， 40。由果糖焦化制备。

5-羟甲基糠醛海关

[ 海关编码 ]: 2932190090

[ 中文概述 ]:
2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

5-羟甲基糠醛文献

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