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丁氧卡因

丁氧卡因用途

奥昔布卡因是一种短效酯类局部麻醉剂,用于眼科和耳鼻咽喉科[1]。

丁氧卡因名称

[ CAS 号 ]:
99-43-4

[ 中文名 ]:
丁氧卡因

[ 英文名 ]:
Oxybuprocaine

[中文别名 ]:

[英文别名 ]:

Benoxinate
Oxybuprocaine
Oxybucaine
Prescaina
Oxibuprocainum
Conjucain
2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate
Benoxil
Oxibuprocaina
Oxibuprokain

丁氧卡因生物活性

[ 描述 ]:

奥昔布卡因是一种短效酯类局部麻醉剂,用于眼科和耳鼻咽喉科[1]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[参考文献]

[1]. Masayuki Kohsaka, et al. Oxybuprocaine for apraxia of lid opening in Parkinson's disease: A placebo-controlled pilot trial. Mov Disord

丁氧卡因物理化学性质

[ 密度 ]:
1.052g/cm3

[ 沸点 ]:
446.9ºC at 760mmHg

[ 分子式 ]:
C₁₇H₂₈N₂O₃

[ 分子量 ]:
308.41600

[ 闪点 ]:
224.1ºC

[ 精确质量 ]:
308.21000

[ PSA ]:
64.79000

[ LogP ]:
3.52750

[ 外观性状 ]:
淡黄色油状物

[ 折射率 ]:
1.524

[ 储存条件 ]:
室温，密闭，干燥

丁氧卡因毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1502000

CHEMICAL NAME :: Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 99-43-4

BEILSTEIN REFERENCE NO. :: 2288926

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H28-N2-O3

MOLECULAR WEIGHT :: 308.47

WISWESSER LINE NOTATION :: 4OR BZ EVO2N2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 37 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 38,265,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 38,265,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,612,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982

丁氧卡因安全信息

[ 海关编码 ]:
2922509090

丁氧卡因合成路线

详细合成路线

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丁氧卡因上游产品

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丁氧卡因海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%