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333963-40-9生产厂家

333963-40-9价格

333963-40-9

333963-40-9结构式
333963-40-9结构式
  • 常用中文名:鲁比前列酮
  • 常用英文名:Lubiprostone
  • CAS号:333963-40-9
  • 分子式:C20H32F2O5
  • 分子量:390.462
  • 相关类别: 生物化工 抑制剂 跨膜转运体(Transmembrane Transporters) CFTR 激活剂
  • 发布时间:2018-05-28 08:00:00
  • 更新时间:2024-01-03 17:15:19
  • Lubiprostone, also known as RU-0211, is a medication used in the management of chronic idiopathic constipation, predominantly irritable bowel syndrome-associated constipation in women and opioid-induced constipation. It was initially approved by the U.S. Food and Drug Administration (FDA) in 2006. Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM).

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中文名 鲁比前列素
英文名 (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid
中文别名 (2R,4AR,5R,7AR)-2-(1,1-二氟戊基)-2-羟基-6-氧代-3,4,4A,5,7,7A-六氢环戊并[B]吡喃-5-庚酸
鲁比前列酮
卢比前列酮
英文别名 (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-h
7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid
Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11α,15R)-
Spi 0211
Lubiprostone
Prostan-1-oic acid,11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-,(11alpha,15R)
(11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid
7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yI]heptanoic acid
[3H]-Lubiprostone
Unii-7662kg2R6k
(-)-7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid
密度 1.2±0.1 g/cm3
沸点 532.3±50.0 °C at 760 mmHg
分子式 C20H32F2O5
分子量 390.462
闪点 275.7±30.1 °C
精确质量 390.221771
PSA 83.83000
LogP 2.85
外观性状 固体
蒸汽压 0.0±3.2 mmHg at 25°C
折射率 1.486
储存条件 -20°C, 干燥
危害码 (欧洲) Xn
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