中文名 | 鲁比前列素 |
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英文名 | Lubiprostone |
中文别名 |
鲁比前列酮
7-[(1R,4R,6R,9R)-4-(1,1-二氟戊基)-4-羟基-8-氧代-5-氧杂双环[4.3.0]壬烷-9-基]庚酸 |
英文别名 |
Prostan-1-oic acid, 11,15-epoxy-16,16-difluoro-15-hydroxy-9-oxo-, (11α,15R)-
13,14-dihydro-15-keto-16,16-difluoro-Prostaglandin E1 9ALPHA-HYDROXY-11,15-DIOXO-PROST-5Z-EN-1-OIC ACID 13,14-dihydro-15-keto Prostaglandin D2 Lipid Maps MS Standard DK-PGD2 (3aR,4R,5R,6aS)-4-[(1E)-4,4-Difluoro-3-oxo-1-octen-1-yl]-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl 4-biphenylcarboxylate 13,14-dihydro-15-keto-prostaglandin D2 [1,1'-Biphenyl]-4-carboxylic acid, (3aR,4R,5R,6aS)-4-[(1E)-4,4-difluoro-3-oxo-1-octen-1-yl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester 13,14-Dihydro-15-keto-PGD2 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl]heptanoic acid 13,14-Dihydro-15-ketoprostadlandin D2 Lubiprostone (11α,15R)-16,16-Difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid 13,14-dihydro-15-keto PD2 13,14-dihydro-15-keto-16,16-difluoro-PGE1 |
描述 | Lubiprostone(SPI-0211;RU0211)是胃肠制剂,可作用于慢性便秘。 |
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相关类别 | |
参考文献 |
密度 | 1.2±0.1 g/cm3 |
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沸点 | 532.3±50.0 °C at 760 mmHg |
熔点 | 56-59ºC |
分子式 | C20H32F2O5 |
分子量 | 390.462 |
闪点 | 275.7±30.1 °C |
精确质量 | 390.221771 |
PSA | 83.83000 |
LogP | 2.85 |
外观性状 | 白色,无气味的晶体或结晶粉末 |
蒸汽压 | 0.0±3.2 mmHg at 25°C |
折射率 | 1.486 |
储存条件 | -20°C Freezer |
符号 |
GHS07 |
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信号词 | Warning |
危害声明 | H315-H319-H335 |
警示性声明 | P261-P305 + P351 + P338 |
危害码 (欧洲) | Xi |
危险品运输编码 | NONH for all modes of transport |
RTECS号 | UK8257750 |
海关编码 | 2918990090 |
~70% 136790-76-6 |
文献:APOTEX PHARMACHEM INC.; KOTHAKONDA, Kiran, Kumar; WANG, Fan; GUNTOORI, Bhaskar, Reddy; NGUYEN, Minh, T.N.; CECCARELLI, Alfredo, Paul; ZHAO, Yajun; KOTIPALLI, Uma; DUNCAN, Sammy, Chris; MILNEE, Kaarina, K.; KELLS, Kevin, W.; MONTEMAYOR, Laura, Kaye Patent: WO2010/83597 A1, 2010 ; Location in patent: Page/Page column 54-55 ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; Page/Page column 13-14 ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; |
~% 136790-76-6 |
文献:WO2011/91513 A1, ; |
上游产品 3 | |
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下游产品 1 | |
海关编码 | 2918990090 |
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中文概述 | 2918990090. 其他含其他附加含氧基羧酸(包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0% |
申报要素 | 品名, 成分含量, 用途 |
Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |