3863-80-7

• 常用中文名：法可林
• 常用英文名：phacolysin
• CAS号：3863-80-7
• 分子式：C₁₈H₁₀N₄Na₂O₆S₂
• 分子量：488.405
• 相关类别： 原料药 专科用药 眼科用药
• 发布时间：2018-06-05 08:00:00
• 更新时间：2024-01-11 22:27:33
• Azapentacene sodium 是一种抗白内障剂。

名称

• 中文名: 法可林
• 英文名: Phacolysine Sodium Salt
• 中文别名: 5,12-二氢喹诺并[2,3-b]吩嗪-2,9-二磺酸钠; 法克林; 治障宁; 睛可明
• 英文别名: Disodium 5,12-dihydroquinoxalino[2,3-b]phenazine-2,9-disulfonate; phacolysin; MFCD08458873; Quinoxalino[2,3-b]phenazine-2,9-disulfonic acid, 5,12-dihydro-, sodium salt (1:2); Azapentacene; Phacolin; Sodium 5,12-dihydroquinoxalino[2,3-b]phenazine-2,9-disulfonate

物化性质

• 分子式: C₁₈H₁₀N₄Na₂O₆S₂
• 分子量: 488.405
• 精确质量: 487.983704
• PSA: 188.52000
• LogP: 4.27760

生物活性

• 描述: Azapentacene sodium 是一种抗白内障剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Shvachko AG, et al. [Chemiluminescence decrease of singlet oxygen in NaClO+H2O2 reaction in the presence of different anti-cataract drugs]. Biull Eksp Biol Med. 1991 Jul;112(7):42-4. Russian.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VD3655000 CAS REGISTRY NUMBER : 3863-80-7 LAST UPDATED : 199712 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C18-H12-N4.2O3-S.2Na MOLECULAR WEIGHT : 458.38 WISWESSER LINE NOTATION : T G6 E6 C666 BM FN MM QNJ &.NA..S-O3 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1900 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1190 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,328,1982