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3414-62-8

3414-62-8结构式

常用中文名：6-n-hydroxyadenosine
常用英文名：6-n-hydroxyadenosine
CAS号：3414-62-8
分子式：C₁₀H₁₃N₅O₅
分子量：283.24100
相关类别：研究领域其他
发布时间：2016-02-23 20:56:53
更新时间：2024-01-03 09:10:55
肌苷肟(6-羟基腺苷)是细胞色素P450、氧化应激或核苷酸生物合成异常引起的细胞代谢过程中的内源性代谢产物。肌苷肟对原核细胞和真核细胞具有毒性和诱变性[1][2]。

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英文名	6-n-hydroxyadenosine
英文别名	N6-Hydroxy-5-methyl-cytosin N6-hydroxyadenosine N-hydroxyadenosine 5-methyl-1H-pyrimidine-2,4-dione 4-oxime 6-(hydroxyamino)-5-methylpyrimidin-2(1h)-one 5-Methyl-N(4)-hydroxycytosine

描述	肌苷肟(6-羟基腺苷)是细胞色素P450、氧化应激或核苷酸生物合成异常引起的细胞代谢过程中的内源性代谢产物。肌苷肟对原核细胞和真核细胞具有毒性和诱变性[1][2]。
相关类别	研究领域 >> 其他
体外研究	肌苷肟(6-羟基腺苷)(1-5nM)通过腺苷脱氨酶催化的直接脱羟化作用还原解毒为肌苷,并通过在HEK-293中敲除mARC1将肌苷形成减少35%。
参考文献	[1]. Plitzko B, et, al. The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine. J Biol Chem. 2015 Apr 17;290(16):10126-35. [2]. Krompholz N, et, al. The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues. Chem Res Toxicol. 2012 Nov 19;25(11):2443-50.

密度	2.12g/cm3
沸点	703.7ºC at 760 mmHg
分子式	C₁₀H₁₃N₅O₅
分子量	283.24100
闪点	379.4ºC
精确质量	283.09200
PSA	149.01000
折射率	1.897

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU6475000

CHEMICAL NAME :: Adenine, N-hydroxy-9-ribofuranosyl-

CAS REGISTRY NUMBER :: 3414-62-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H13-N5-O5

MOLECULAR WEIGHT :: 283.28

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IMQ DO1- BT5OTJ CQ DQ EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 700 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ng/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 144,231,1985

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