85999-40-2

• 常用中文名：23-羟基白桦酸
• 常用英文名：Anemosapogenin
• CAS号：85999-40-2
• 分子式：C₃₀H₄₈O₄
• 分子量：472.700
• 相关类别： 生物化工 中草药成分
• 发布时间：2018-07-01 20:10:11
• 更新时间：2024-01-06 20:09:38
• 23-hydroxybetulinic acid是具有抗癌活性的生物化合物。

名称

• 中文名: 23-羟基白桦酸
• 英文名: (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aS,13bR)-9-hydroxy-8-(hydroxymethyl)-5a,5b,8,11a-tetramethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid
• 英文别名: (3β,13α)-3,23-Dihydroxylup-20(29)-en-28-oic acid; Lup-20(29)-en-28-oic acid, 3,23-dihydroxy-, (3β,13α)-; Anemosapogenin; (3β)-3,23-Dihydroxylup-20(29)-en-28-oic acid; 23-Hydroxybetulinic acid; 3|A,23-Dihydroxylup-20(29)-en-28-oic acid; Lup-20(29)-en-28-oic acid, 3,23-dihydroxy-, (3β)-; 23-hydroxy butulinic acid; 23-HBA

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 585.8±25.0 °C at 760 mmHg
• 熔点: 305 °C
• 分子式: C₃₀H₄₈O₄
• 分子量: 472.700
• 闪点: 322.1±19.7 °C
• 精确质量: 472.355255
• PSA: 77.76000
• LogP: 7.29
• 外观性状: 固体;White to Light yellow powder to crystal
• 蒸汽压: 0.0±3.7 mmHg at 25°C
• 折射率: 1.543
• 储存条件: -20°C;存放于惰性气体之中;避免光,湿气 (分解),加热

生物活性

• 描述: 23-hydroxybetulinic acid是具有抗癌活性的生物化合物。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
  天然产物 >> 酸和醛
• 参考文献:

  [1]. Liu M et al. Cytotoxicity of the compounds isolated from Pulsatilla chinensis saponins and apoptosis induced by 23-hydroxybetulinic acid. Pharm Biol. 2015 Jan;53(1):1-9.

  [2]. Zhang DM et al. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Mol Pharm. 2012 Nov 5;9(11):3147-59.

  [3]. Zheng Y et al. 23-Hydroxybetulinic acid from Pulsatilla chinensis (Bunge) Regel synergizes the antitumor activities of doxorubicin in vitro and in vivo. J Ethnopharmacol. 2010 Apr 21;128(3):615-22.

合成路线

136684-40-7 ~86% 85999-40-2

文献：Sun, Fei; Zhu, Peiqing; Yao, Hequan; Wu, Xiaoming; Xu, Jinyi Journal of Chemical Research, 2012 , vol. 36, # 5 p. 254 - 257

1256959-22-4 ~% 85999-40-2

文献：Journal of Chemical Research, , vol. 36, # 5 p. 254 - 257

1256959-23-5 ~% 85999-40-2

文献：Journal of Chemical Research, , vol. 36, # 5 p. 254 - 257

1256959-24-6 ~% 85999-40-2

文献：Journal of Chemical Research, , vol. 36, # 5 p. 254 - 257

1256959-25-7 ~% 85999-40-2

文献：Journal of Chemical Research, , vol. 36, # 5 p. 254 - 257

472-15-1 ~% 85999-40-2

文献：Journal of Chemical Research, , vol. 36, # 5 p. 254 - 257

192211-42-0 ~% 85999-40-2

文献：Journal of Chemical Research, , vol. 36, # 5 p. 254 - 257

203576-71-0 ~% 85999-40-2

文献：Journal of Chemical Research, , vol. 36, # 5 p. 254 - 257

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