100427-26-7

• 常用中文名：乐卡地平
• 常用英文名：Lercanidipine
• CAS号：100427-26-7
• 分子式：C₃₆H₄₁N₃O₆
• 分子量：611.727
• 相关类别： 原料药 循环系统用药 钙通道阻滞剂
• 发布时间：2018-08-31 09:57:29
• 更新时间：2024-01-03 12:06:17
• Lercanidipine是钙离子通道阻断剂。

名称

• 中文名: 乐卡地平
• 英文名: 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• 中文别名: 1,4-双氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸 2-[(3,3-二苯丙基)甲氨基]-1,1-二甲基乙基甲酯
• 英文别名: 1-[(3,3-diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 5-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[(3,3-Diphenylpropyl)methylamino]-1,1-dimethylethyl Methyl Ester; lercarnidipine; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester; methyl 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate; masnidipine; Methyl 1,1-Dimethyl-2-[N-(3,3-diphenylpropyl)-N-methylamino]ethyl 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methyl-2-propanyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate; Lercanidipine [INN]; UNII:V7XTJ4R0BH; Lercanil (TN); (±)-2-((3,3-diphenylpropyl)(methyl)amino)-1,1-dimethylethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; REC 15-2375; MFCD00867978; UNII-V7XTJ4R0BH; 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester; Lercanidipine

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 712.5±60.0 °C at 760 mmHg
• 熔点: 118-120ºC
• 分子式: C₃₆H₄₁N₃O₆
• 分子量: 611.727
• 闪点: 384.7±32.9 °C
• 精确质量: 611.299561
• PSA: 113.69000
• LogP: 8.04
• 外观性状: 白色至淡黄色固体
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.580

生物活性

• 描述: Lercanidipine是钙离子通道阻断剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钙通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70.

  [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.

安全

• 海关编码: 2942000000

合成路线

132866-11-6 ~76% 100427-26-7

文献：Recordati Ireland Limited Patent: US2006/199849 A1, 2006 ; Location in patent: Page/Page column 7-8 ;

28075-29-8 ~% 100427-26-7

文献：European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

74936-72-4 ~% 100427-26-7

文献：European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

100442-33-9 ~% 100427-26-7

文献：European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

100427-51-8 ~% 100427-26-7

文献：European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

88712-56-5 100442-33-9 ~% 100427-26-7

文献：European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

100427-53-0 21731-17-9 ~% 100427-26-7

文献：US2006/199849 A1, ; Page/Page column 8 ;

21731-17-9 210579-45-6 ~% 100427-26-7

文献：European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420

上下游产品

上游产品  9
132866-11-6 28075-29-8 74936-72-4 100442-33-9
100427-51-8 88712-56-5 100427-53-0 21731-17-9
210579-45-6
下游产品  1
132866-11-6

海关

海关编码	2942000000