147118-39-6

• 常用中文名：瑞舒伐他汀中间体H-2
• 常用英文名：5-Oxorosuvastatin Methyl Ester
• CAS号：147118-39-6
• 分子式：C₂₃H₂₈FN₃O₆S
• 分子量：493.548
• 发布时间：2018-09-10 21:46:17
• 更新时间：2024-01-09 21:01:31

名称

• 中文名: 瑞舒伐他汀钙中间体六
• 英文名: 7-[4-fluorophenyl]-6-isopropyl)-2-(N-Methyl-N-MethylSulfonyl amino)pyrimidine-5-yl]-(3R)-3-(terbutyldimethylsilyloxy)-5-oxo-6E-heptane acid,Methyl ester
• 中文别名: (3R,5S,6E)-7-[4-(4-氟苯基)-6-异丙基-2-(N-甲基甲磺酰基胺基-5-嘧啶)]-3-羟基-5-氧代-6-庚烯酸甲酯
• 英文别名: Methyl 7-[4-(4-FLUOROPHENYL)-6-ISO-PROPYL-2-(N-METHYL-N-METHYLSULFONYLAMINO)PYRIMIDIN-5-YL]-(3R,5R)-DIHYDROXY-(E)-6-HEPTENATE; (R,E)-Methyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)-3-hydroxy-5-oxohept-6-enoate; methyl (3R,6E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl]-3-hydroxy-5-oxohept-6-enoate; Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate; Methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3-hydroxy-5-oxohept-6-enoate; methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptanate; Methyl (3R,6E)-7-{4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl}-3-hydroxy-5-oxo-6-heptenoate; methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)-pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate; methyl 7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenate; methyl 7-[4-(4-flourophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R)-3-hydroxy-5-oxo-(E)-6-heptenoate; Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methanesul fonylaMino) pyriMidin-5-y; 7-[4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl-methyl-amino)pyrimidin-5-yl]-3-hydroxy-5-oxo-hept-6-enoic acid methyl ester; 5-Oxorosuvastatin methyl ester; 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-, methyl ester, (3R,6E)-; ZD-6; (3R,6E)-7-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3-hydroxy-5-oxo-6-heptenoic acid methyl ester; Methyl (+)-(3R)-7-[4-(4-fluorophenyl)- 6-isopropyl-2-(N-Methyl-NMethansulphonylaMino) pyriMidin-5-yl]-3-hydroxy-5-oxo- 6(E)-heptenoate; methyl (3R,6E)-7-[4-(4-flurophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)mino]-5-pyrimidyl]-3-hydroxy-5-oxo-6-heptenoate

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 701.7±70.0 °C at 760 mmHg
• 分子式: C₂₃H₂₈FN₃O₆S
• 分子量: 493.548
• 闪点: 378.2±35.7 °C
• 精确质量: 493.168274
• PSA: 135.14000
• LogP: 1.40
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.569
• 储存条件: 2-8°C

合成路线

上下游产品

上游产品  8
147118-38-5 147118-35-2 147118-37-4 91424-40-7
459-57-4 147118-27-2 147118-36-3 147118-28-3
下游产品  2
287714-41-4 147118-40-9