38099-82-0

• 常用中文名：D-果糖-1,6-二磷酸三钠
• 常用英文名：D-Fructose 1,6-bisphosphate trisodium salt
• CAS号：38099-82-0
• 分子式：C₆H₁₁Na₃O₁₂P₂
• 分子量：406.061
• 相关类别： 有机原料 有机金属盐
• 发布时间：2018-12-05 17:19:55
• 更新时间：2024-01-06 19:10:03
• Fosfructose trisodium (Diphosphofructose trisodium;Esafosfan trisodium;FDP trisodium) 是一种细胞保护性的天然糖磷酸盐,用于治疗心血管缺血,镰状细胞性贫血和哮喘。 它通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷。

名称

• 中文名: D-果糖-1,6-二磷酸三钠,八水
• 英文名: D-Fructose 1,6-bisphosphate trisodium salt
• 中文别名: 果糖二磷酸钠; D-果糖-1,6-二磷酸三钠盐,无水; D-果糖-1,6-二磷酸三钠盐; 1,6-二磷酸果糖三钠盐
• 英文别名: D-fructose 1,6-bis(dihydrogen phosphate),trisodium salt; HEXOSE DIPHOSPHATE; O1,O6-Diphosphono-D-fructose,Trinatrium-Salz; O1,O6-diphosphono-D-fructose,trisodium-salt; hexose diphosphoric acid; 1,6-bis(dihydrogen phosphate),sodium salt; 6-diphosphate trisodiuM salt octahydrate; HARDEN-YOUNG ESTER; Trisodium 1-O-(hydroxyphosphinato)-6-O-phosphonato-D-fructose; D-FRUCTOSE 1,6-DIPHOSPHATE TRISODIUM SALT; HEXOSE DIPHOSPHATE TRISODIUM SALT; D-Fructose, 1,6-bis(dihydrogen phosphate), sodium salt (1:3); D-Fructose-1; FDP-Na3H

物化性质

• 密度: 2.095g/cm3
• 沸点: 722.6ºC at 760mmHg
• 熔点: 127ºC
• 分子式: C₆H₁₁Na₃O₁₂P₂
• 分子量: 406.061
• 闪点: 390.8ºC
• 精确质量: 405.941895
• PSA: 231.55000
• 外观性状: 白色粉末或晶体
• 储存条件: −20°C

生物活性

• 描述: Fosfructose trisodium (Diphosphofructose trisodium;Esafosfan trisodium;FDP trisodium) 是一种细胞保护性的天然糖磷酸盐,用于治疗心血管缺血,镰状细胞性贫血和哮喘。 它通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷。
• 相关类别:
  研究领域 >> 心血管疾病
• 靶点:

  Endogenous Metabolite[1]

• 参考文献:

  [1]. Folkesson HG, et al. Fosfructose (Questcor). IDrugs. 2001 Dec;4(12):1401-7.

MSDS

Name: D-Fructose-1 6-Diphosphate Trisodium Salt Hydrate Material Safety Data Sheet Synonym: None Known CAS: 38099-82-0 Section 1 - Chemical Product MSDS Name:D-Fructose-1 6-Diphosphate Trisodium Salt Hydrate Material Safety Data Sheet Synonym:None Known Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 38099-82-0 D-Fructose-1,6-Diphosphate Trisodium S ca. 100 253-778-0 Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin.Moisture sensitive. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Causes respiratory tract irritation. May cause nausea and possible vomiting. Can produce delayed pulmonary edema. Chronic: Effects may be delayed. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Do NOT get water inside containers. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Do not get water inside containers. Section 7 - HANDLING and STORAGE Handling: Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Do not allow contact with water. Wash clothing before reuse. Keep from contact with moist air and steam. Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated. (Store below 4C/39F.) Store protected from moisture. Store under argon. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 38099-82-0: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Crystalline powder Color: white to light yellow Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C6H11Na3O12P2.xH2O Molecular Weight: 405.9868 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Moisture sensitive. Conditions to Avoid: Incompatible materials, dust generation, excess heat, exposure to moist air or water. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of phosphorus, carbon dioxide. Hazardous Polymerization: Will not occur. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 38099-82-0 unlisted. LD50/LC50: Not available. Carcinogenicity: D-Fructose-1,6-Diphosphate Trisodium Salt Hydrate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: IMO Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 38099-82-0: No information available. Canada CAS# 38099-82-0 is listed on Canada's DSL List. CAS# 38099-82-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 38099-82-0 is listed on the TSCA inventory. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• WGK德国: 3